ISSN : 2146-3123
E-ISSN : 2146-3131

Quercetin, a Powerful Antioxidant Bioflavonoid, Prevents Oxidative Damage in Different Tissues of Long-Term Diabetic Rats
Mustafa Edremitlioğlu 1, Mehmet Fatih Andiç 2, Oğuzhan Korkut 3
1Department of Physiology, Faculty of Medicine, Çanakkale Onsekiz Mart University, Çanakkale, Turkey
2Application and Research Hospital, Konya, Turkey
3Department of Pharmacology, Faculty of Medicine, Balıkesir University, Balıkesir, Turkey
DOI : 10.5152/balkanmedj.2011.002
Pages : 49-55

Abstract

Objective: The role of oxidant damage on the development of end-organ injuries caused by diabetic rat is well known. The aim of this study is to examine the effect of quercetin, which is a strong antioxidant bioflavonoid, on oxidant damage and antioxidant capacity in various organs in the case of medium-term or long-term diabetic rat.

Material and Methods: Forty-eight male Wistar rats were divided into five groups, namely, control group, diabetic group of 8-weeks, diabetic group of 16-weeks, quercetin treated diabetic group of 8-weeks, and quercetin treated diabetic group of 16-weeks. At the end of the experiment, malondialdehyde levels, superoxide dismutase, catalase, and glutathione peroxidase activities were measured in the lung, aorta, heart, spleen, liver, and kidney tissues.

Results: MDA levels were elevated in all tissues except in the lung in non-treated diabetic groups. Quercetin treatment increased the antioxidant enzyme capacities and considerably reduced oxidant damage.

Conclusion: We suggest that quercetin has a protective effect on the aorta, heart, brain, liver, and kidneys from oxidant damage in the case of mediumterm or long-term diabetic rat. It can be argued that quercetin is effective by increasing the antioxidant defence capacity in this process.

Keywords : Quercetin, diabetic rat, oxidative damage, antioxidant enzymes
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