ISSN : 2146-3123
E-ISSN : 2146-3131

PD-L1 Expression in Non Small Cell Lung Cancer and Prognosis
Songül Şahin1, Şebnem Batur2, Övgü Aydın2, Tülin Öztürk2, Akif Turna3, Büge Öz2
1Pathology Laboratory, Çankırı State Hospital, Çankırı, Turkey
2Department of Pathology, İstanbul University, Cerrahpaşa School of Medicine, İstanbul, Turkey
3Department of Thoracic Surgery, İstanbul University, Cerrahpaşa School of Medicine, İstanbul, Turkey
DOI : 10.4274/balkanmedj.2018.0392

Background: Prognostic significance of programmed death-ligand-1 (PD-L1) status in non-small cell lung carcinoma (NSCLC) is controversial.
Aims: In this study, we aimed to show the PD-L1 expression status in our patient population with NSCLC and its effect on prognosis and relationship with clinicopathologic data.
Study Design: The study was retrospective cross-sectional study and included 208 cases (107 had squamous cell carcinoma (SCC), 72 had adenocarcinoma (AC), and 29 had other types of NSCLC) who underwent surgery between 2001 and 2012.
Methods: PD-L1 (SP142 clone) was applied on the sections acquired from the microarray paraffin block with immunohistochemistry (IHC).
Results: Four different threshold values were used in our study and all clinical and pathologic parameters were compared with the PD-L1 results obtained from these threshold values. PD-L1 expression was observed in patients with NSCLS independent of the histological type or subtype.
Conclusion: In conclusion, PD-L1 expression is observed in NSCLC in parallel to the literature and it can be used as a negative prognostic indicator independent from the treatment method selected.

Keywords : PD-L1, lung, NSCLC, prognosis
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