ISSN : 2146-3123
E-ISSN : 2146-3131

Prognostic Value of Lymph Node Ratio for Colorectal Cancer
İlker Sücüllü 1, Yavuz Kurt 1, Sevim Özdemir 2, Ali İlker Filiz 3, Mehmet Yıldız 4
1Gülhane Askeri Tıp Akademisi Haydarpaşa Eğitim Hastanesi, Genel Cerrahi Kliniği, İstanbul, Türkiye
2İstanbul Üniversitesi, Cerrahpaşa Tıp Fakültesi, Radyasyon Onkolojisi Bilim Dalı, İstanbul, Türkiye
3Department of General Surgery, Gülhane Military Medical Academy, Haydarpaşa Training Hospital, İstanbul, Turkey
4Department of Dentistry, Atatürk University Dental Faculty, Erzurum, Turkey
DOI : 10.5174/tutfd.2009.03164.1
Pages : 86-90

Abstract

Objective: This study was designed to assess the prognostic value of lymph node ratio (LNR) in patients with nonmetastatic colorectal cancer treated with radical resection.

Material and Methods: The characteristic and pathologic parameters of 280 patients operated on for nonmetastatic colorectal cancer at our service were recorded retrospectively. Patients were stratified into 4 groups according to the LNR quartiles of 1/12, ¼, ½ and 1. Distribution of demographic data and probability tables were made by ANOVA and χ2 tests. The cumulative survival ratios for LNR, N stage and TNM stage were calculated by the Kaplan Meier method and survival difference between groups were calculated by the log rank test.

Results: There was a statistically significant correlation ratio between metastatic lymph node count and LNR. In 173 of all patients (61.8%) fewer than 12 lymph nodes were harvested. One hundred sixtysix (59.3%) patients were evaluated as N0, 79 (28.2%) were N1 and 35 (12.5%) were N2. The number of patients in 4 groups of LNR were 174 (62.1%), 72 (25.7%), 22 (7.9%) and 12 (4.3% ) respectively. Five year survival ratios were 82,8% in LNR1, 69.4% in LNR2, 58.3% in LNR3 and 50% in LNR4. The difference for survival times and ratios between these groups were significantly difference (p=0.001).

Conclusion: LNR may help physicians to decide the adequate treatment and estimate the prognosis in patients with inadequate lymphadenectomy.

Keywords : Colorectal cancer, lymph nod ratio, staging, prognosis
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