ISSN : 2146-3123
E-ISSN : 2146-3131

Adherence to Nucleoside/Nucleotide Analogue Treatment in Patients with Chronic Hepatitis B
E. Ediz Tütüncü1, Rahmet Güner2, Yunus Gürbüz1, Ayşe Kaya Kalem3, Barış Öztürk1, İmran Hasanoğlu3, İrfan Şencan1, Mehmet A. Taşyaran2
1Department of Infectious Diseases and Clinical Microbiology, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey
2Department of Infectious Diseases and Clinical Microbiology, Yıldırım Beyazıt University School of Medicine, Ankara, Turkey
3Department of Infectious Diseases and Clinical Microbiology, Ankara Atatürk Training and Research Hospital, Ankara, Turkey
DOI : 10.4274/balkanmedj.2016.1461

Background:Adherence to medication is an important aspect for preventing drug resistance and treatment failure in patients receiving nucleos(t)ide analogues for chronic hepatitis B.
Aims:To assess adherence to nucleoside/nucleotide analogues (NAs) in chronic hepatitis B (CHB) treatment and to determine factors associated with non-adherence.
Study Design:Cross-sectional study.
Methods:The study enrolled 85 CHB patients who have been receiving NAs for ≥ 3 months. A questionnaire was completed by patients themselves and adherence was evaluated based on patients’ self-reporting. The use of at least 95% of the drugs in the previous month was considered as adequate adherence.
Results:Adherence was adequate in 82.4% of patients. Female gender (p=0.003), unemployment (p=0.041), and lower monthly family income (p=0.001) were related to lower adherence. Better adherence was significantly linked to adequate basic knowledge regarding CHB (p=0.049), longer treatment duration than 12 months (p<0.001), previous use of other medications for CHB (p=0.014), and regular follow-up by the same physician (p<0.001).
Conclusion:Counseling patients about their disease state, and consequences of non-adherence is an important intervention in enhancing adherence. Naïve patients should be followed-up more frequently to reinforce adherence.

Keywords : Patient adherence, chronic hepatitis B, therapy
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