ISSN : 2146-3123
E-ISSN : 2146-3131

Mixed Adeno-Neuroendocrine Carcinoma; Case Series of Ten Patients with Review of the Literature
Yiğit Düzköylü1, Orhan Aras1, Erdal Birol Bostancı1, Tülay Keklik Temuçin2, Murat Ulaş1
1Clinic of Gastroenterological Surgery, Türkiye Yüksek İhtisas Training and Research Hospital, Ankara, Turkey
2Clinic of Pathology, Türkiye Yüksek İhtisas Training and Research Hospital, Ankara, Turkey
DOI : 10.4274/balkanmedj.2017.1471
Pages : 263-267


Aims: Mixed adeno-neuroendocrine carcinoma is a rare entity, diagnosed with immunohistochemical studies. Literature mainly includes case reports and series which are very few. In our study, we aimed to report a case series from a tertiary hospital with demographics of the patients, detailed tumor and clinical findings and follow-up plus survival conditions.
Methods: Pathology database was explored for patients with the pathological diagnosis of ‘mixed adeno-neuroendocrine carcinoma’ and patients were identified retrospectively and evaluated in means of demographics, histopathological examination, tumor properties.Results:  Ten patients had been diagnosed with mixed adeno-neuroendocrine carcinoma in our center, diagnosed at a mean age of 64.7.  Stomach was found to be the most common localization. Five patients (50%) were diagnosed as grade 3. Following surgery, median follow-up was 15 months with a median survival time of 20.6 months.
Conclusion: This case series may contribute to the literature on the pathological and clinical aspects of the mixed adenoneuroendocrine carcinoma of the gastrointestinal system.

Keywords : Digestive system, mixed adenoneuroendocrine carcinoma, neuroendocrine neoplasm, prognosis
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