ISSN : 2146-3123
E-ISSN : 2146-3131

Effect of Intracameral Ophthalmic Cefuroxime Solution (Aprokam®) in Prophylaxis of Cataract Surgery in Patients with Keratoplasty
Mustafa Erdoğan Cicik1, Cezmi Doğan1, Osman Şevki Arslan1
1Department of Ophthalmology, İstanbul University, Cerrahpaşa School of Medicine, İstanbul, Turkey
DOI : 10.4274/balkanmedj.2017.1493
Background: Development of endophthalmitis during cataract surgery is one of the most severe complications and it may result in blindness and globe loss.
Aims: Evaluation of the effect of ophthalmic cefuroxime solution (Aprokam®) which is prophylactically used in phacoemulsification surgery performed due to cataract that eventually occurs in patients who underwent for penetrating keratoplasty or without keratoplasty.
Study Design: Case-control study.
Methods: It is a retrospective study and patients who had undergone for penetrating keratoplasty, for whom phacoemulsification surgery was performed due to cataract and intracameral ophthalmic cefuroxime solution (Aprokam®) was administered for prophylaxis were evaluated in comparison with cataract patients without keratoplasty. In this retrospective study, postoperative anterior chamber reaction, intraocular pressure, best corrected visual acuity, corneal endothelial cell density and central corneal thickness alterations were evaluated.
Results: Forty-two patients (18 male, 24 female) with keratoplasty and 42 (17 male, 25 female) without keratoplasty were included in the study. In all of the patients, increase in visual acuity was observed after cataract surgery. The mean corneal endothelial cell densities were determined to be 2437.20±148.5 cells/mm2 preoperatively in the study group and 2807.1±152.4 cells/mm2 preoperatively in the control group. The mean corneal endothelial cell densities were determined to be 2103.85±196.5 cells/mm2 after the first postoperative month (p<0.001) in the study group and 2755.92±182.7 cells/mm2 in the control group (p=0.17). The central corneal thicknesses in the study group were 565.78±11.5 µm preoperatively and 584.65±12.7 µm after the first postoperative month (p<0.001). The central corneal thicknesses in the control group were 562.81±12.5 µm preoperatively and 564.72±9.3 µm after the first postoperative month. No difference was observed in the control group in terms of preoperative and postoperative central corneal thicknesses (p=0.43).
Conclusion: While there was a significant decrease in the corneal endothelial cell density of the patients with keratoplasty for whom cataract surgery was performed at the postoperative 1st month, no significant difference was observed in the control group. No significant toxic effect of the prophylactic intracameral use of ophthalmic cefuroxime solution (Aprokam®), which is used in patients with keratoplasty for whom cataract surgery was performed, has been determined.
Keywords : Cefuroxime solution, aprokam, keratoplasty, cataract surgery
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