ISSN : 2146-3123
E-ISSN : 2146-3131

Osteoprotegerin's Role as a Cardioprotective Versus Reactive Inflammatory Marker: Chicken or the Egg Paradox
Flora Özkalaycı1, Öykü Gülmez1, Betül Uğur-Altun2, Seithikurippu Ratnas Pandi-Perumal3, Armağan Altun1
1Department of Cardiology, Başkent University İstanbul Hospital, İstanbul, Turkey
2Department of Endocrinology and Metabolism, Başkent University İstanbul Hospital, İstanbul, Turkey
3Somnogen Canada Inc., College Street, Toronto, ON, Canada
DOI : 10.4274/balkanmedj.2018.0579

Cardiovascular disease is one of the most frequent causes of mortality and morbidity worldwide. There have been many variables identified as risk factors for cardiovascular disease. During the recent years, the role of receptor activator of nuclear factor kappa B, receptor activator of nuclear factor kappa B ligand and osteoprotegerin system are getting more remarkable in the pathogenesis of cardiovascular disease. Besides its role in the regulation of bone resorption system, these molecules are found to be associated with the pathophysiology of cardiovascular disease. There are conflicting data about the impact of osteoprotegerin, a glycoprotein on the regulatory role in the cardiovascular system. The review aims to discuss the current knowledge and the role of osteoprotegerin in cardiovascular disease.

Keywords : Cardiovascular disease, osteoprotegerin
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