ISSN : 2146-3123
E-ISSN : 2146-3131

The Role of Osteoprotegerin as a Cardioprotective Versus Reactive Inflammatory Marker: the Chicken or the Egg Paradox
Flora Özkalaycı1, Öykü Gülmez1, Betül Uğur-Altun2, Seithikurippu Ratnas Pandi-Perumal3, Armağan Altun1
1Department of Cardiology, Başkent University İstanbul Hospital, İstanbul, Turkey
2Department of Endocrinology and Metabolism, Başkent University İstanbul Hospital, İstanbul, Turkey
3Somnogen Canada Inc., College Street, Toronto, Canada
DOI : 10.4274/balkanmedj.2018.0579
Pages : 225-232
Recently, the role of receptor activator of nuclear factor kappa B, receptor activator of nuclear factor kappa B ligand, and the osteoprotegerin system has been recognized as more important in the pathogenesis of cardiovascular disease. No consensus is yet available on the function of osteoprotegerin, but all these studies have concluded that osteoprotegerin is a promising biomarker for coronary artery disease, regardless of whether it plays a protective role against atherosclerosis or causes atherosclerosis with its proatherogenic features.

Abstract

Cardiovascular disease is one of the most frequent causes of mortality and morbidity worldwide. Several variables have been identified as risk factors for cardiovascular disease. Recently, the role of receptor activator of nuclear factor kappa B, receptor activator of nuclear factor kappa B ligand, and the osteoprotegerin system has been recognized as more important in the pathogenesis of cardiovascular disease. Besides their roles in the regulation of bone resorption, these molecules have been reported to be associated with the pathophysiology of cardiovascular disease. There are conflicting data regarding the impact of osteoprotegerin, a glycoprotein with a regulatory role in the cardiovascular system. The aim of this review is to discuss the current knowledge and the role of osteoprotegerin in cardiovascular disease.

Keywords : Cardiovascular disease, heart, inflammatory markers, osteoprotegerin
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