ISSN : 2146-3123
E-ISSN : 2146-3131

Association of Tryptophan Hydroxylase-2 Gene rs4290270 with Primary Insomnia and Depressive Symptoms in a Chinese Han Population
Feng Mei1, Yanfeng Wu2, Jin Wu2
1Department of Medical Psychology, Affiliated Nanjing Brain Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
2Department of Neurology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
DOI : 10.4274/balkanmedj.2017.1406

Background: Insomnia often coexists with depression, and there is compelling evidence for a genetic component in the etiologies of both disorders.
Aims: We genotyped an exonic variant, rs4290270, in tryptophan hydroxylase-2 (TPH-2) gene to investigate its association with primary insomnia in Han Chinese, and further with depression symptoms in patients with primary insomnia.
Study Design: Retrospective cross-sectional study.
Methods: This study included 152 patients with primary insomnia and 164 age- and gender-matched normal controls. Neuropsychological tests were performed.
Results: The genotype distributions of TPH-2 gene rs4290270 met the Hardy-Weinberg equilibrium in both patients and controls (P>0.05). The allele and genotype distributions of this variant were comparable between patients and controls in all subjects and by genders (all P>0.05). The impact of rs4290270 on SDS score changes was statistically significant (P=0.002), with carriers of A/A genotype having the highest self-rating depression scale (SDS) score (mean ± standard deviation: 52.73±12.88), followed by A/T genotype (50.94±11.29, P=0.35) and T/T genotype (43.48±7.78, P<0.01), and this impact was more obvious in women (P<0.001).
Conclusions: Our findings indicate that TPH-2 gene rs4290270 may not be a susceptibility locus for primary insomnia in Han Chinese, but may be a marker of depressive symptoms, especially SDS score, in patients with primary insomnia.

Keywords : Primary insomnia, tryptophan hydroxylase-2, depression, variant
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