ISSN : 2146-3123
E-ISSN : 2146-3131

Evaluating the Effects of a Topical Preparation Composed of Dexpanthenol, Silbiol, Undecylenic Acid and Lidocaine on Palatal Mucosa Wound Healing in a Rat Model
Yasemin Sezgin1, Mehtap Bilgin Çetin1, Şule Bulut1, Nilgün Özlem Alptekin1, Pelin Börçek2
1Department of Periodontology, Başkent University School of Dentistry, Ankara, Turkey
2Department of Pathology, Başkent University School of Medicine, Ankara, Turkey
DOI : 10.4274/balkanmedj.2018.0167

Background: Although postoperative complications occurs after periodontal plastic surgeries, an ideal treatment has not been found to overcome.
Aims: The aim of this study was evaluated the effects of topically applied Oral-norm gel on the healing of excisional wounds.
Study Design: Animal experimentation.
Methods: Excisional wounds with a 3 mm diameter were made in the center of the palatal mucosa in 63 Sprague Dawley rats. Seven animals were sacrificed at time 0. The remaining animals were divided into an experimental group to which topical Oral-norm gel was applied three times a day, and a control group to which nothing was applied. Seven animals in each group were sacrificed at 3, 7, 14 and 21 days. The mean wound surface area (MWSA) was measured, wound healing and width was evaluated microscopically.
Results: The MWSA decreased significantly after 3 days in both groups (p<0.001). After 3 days, the MWSA decreased from 6.62 (2.85) mm2 to 0.83(1.62) mm2 in control group and 5.07(0.88) mm2 to 1.42(1.67) mm2 in test group on day 7. The wound width decreased significantly on day 7 in both groups (p<0.001), with no further changes by day 14. Both groups had a significant increase in inflammation and vascularization on day 3 (p<0.001), with a reduction thereafter. No significant differences in macroscopic and microscopic measurements were observed between the groups at any time point (p>0.05).
Conclusions: No positive healing benefits were observed with the use of Oral-norm gel.

Keywords : excisional, hard palate, Oral-norm, rat, wound healing
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