ISSN : 2146-3123
E-ISSN : 2146-3131

Elevated Serum MCP-1/CCL2 Levels are Linked with Disease Severity in Patients with Fibromyalgia Syndrome
Yuan-Chuang Zhao1, Ting-Hu2, Yan-Chen3, Ke-Tao Du3
1Department of Rehabilitation of Traditional Chinese Medicine, Guangdong Provincial Corps Hospital of Chinese People’s Armed Police Forces, Guangzhou Medical University, Guang Dong Province, China
2Beijing International Travel Healthcare Center, Beijing, China
3Department of Rehabilitation, Chenzhou No.1 People’s Hospital, Chenzhou, Hunan Province, China
DOI : 10.4274/balkanmedj.galenos.2019.2019.6.47

Background: Elevated monocyte chemotactic protein-1/chemokine C-C motif ligand 2 (MCP-1/CCL-2) levels have been identified in fibromyalgia (FM) patients.
Aim: The current study was conducted to examine the potential association among serum MCP-1/CCL2 levels with disease severity of FM.
Study Design: Cross-sectional study.
Methods: Seventy-nine female FM patients and 75 healthy normal controls were incorporated in our study. Serum MCP-1/CCL2 levels were explored by enzyme linked immune sorbent assays. The existence of tender points was evaluated based on the standardized manual tender point examination. The pressure pain thresholds at knees and bilateral trapezius muscles were measured by the Algometer. The visual analogue scale (VAS) and revised Fibromyalgia Impact Questionnaire (FIQ) were utilized to assess degree of pain and functional abilities.
Results: Serum MCP-1/CCL2 levels were suggestively greater in FM patients compared with healthy controls (151.6±31.9 pg/mL vs 103.3±25.2 pg/mL, P<0.001). Severe FM patients had significantly higher CCL2 levels in serum than mild and moderate FM patients (173.1±21.9 pg/mL vs 151.0.0±35.1 pg/mL, P=0.01). Moderate FM patients revealed markedly augmented levels of CCL2 in serum compare to mild patients (151.0±35.1pg/mL vs 133.3±23.9 pg/mL, P=0.03). Serum CCL2 levels were positively associated with tender point scores (r=0.455, P<0.001). Additionally, serum CCL2 levels were also positively associated with the pressure pain thresholds in both knees and bilateral trapezius muscles (knees: r=-0.349, P=0.002; trapezius muscles: r=-0.318, P=0.004). Lastly, we found elevated serum CCL2 levels were also positively associated with VAS (r=0.368, P=0.001) and FIQ score (r=0.401, P<0.001).
Conclusion: Elevated serum MCP-1/CCL2 levels are linked with disease severity of FM. Therapeutic interventions inhibiting MCP-1/CCL2 in FM deserves additional studies.

Keywords : Monocyte chemotactic protein-1; chemokine C-C motif ligand 2; fibromyalgia; disease severity
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