ISSN : 2146-3123
E-ISSN : 2146-3131

The Evaluation of Vitamin K Status in Children with Febrile Seizure
Kürşat Bora Carman1, Yasemin Karal2, Gül Gülen Mert3, Arzu Ekici4, Peren Perk5, Coşkun Yarar1, Çağatay Nuhoğlu6, Gürkan Bozan7, Ömer Kılıç7, Meltem Dinleyici7, Sabiha Şahin7, Emrah Atay8, Uğur Tokdemir7, Baver Demir5, Ener Çağrı Dinleyici7
1Department of Pediatric Neurology, Eskişehir Osmangazi University School of Medicine, Eskişehir, Turkey
2Department of Pediatrics, Trakya University School of Medicine, Edirne, Turkey
3Department of Pediatric Neurology, Çukurova University School of Medicine, Adana, Turkey
4Clinic of Pediatric Neurology, Yüksek İhtisas Hospital, Bursa, Turkey
5Gaziantep Children’s Hospital, Gaziantep, Turkey
6Clinic of Pediatrics, Haydarpasa Numune Training and Research Hospital, İstanbul, Turkey
7Department of Pediatrics, Eskişehir Osmangazi University School of Medicine, Eskişehir, Turkey
8Department of Public Health, Eskişehir Osmangazi University School of Medicine, Eskisehir, Turkey
DOI : 10.4274/balkanmedj.galenos.2020.2020.5.70

Background: Febrile seizure (FS) is the most common neurological disorder of childhood. The exact pathophysiology of FS is unknown. Recent studies showed that the role of vitamin K in non-hematological and inflammatory disorders. The present study aimed to investigate serum vitamin K levels in children with FS.
Aim: To evaluate the vitamin K levels in children with febrile seizure.
Study Design: Prospective case-control study
Methods: This multicenter study examined representative populations in eight different cities in Turkey between April 1, 2018 and April 1, 2019. Blood samples were taken from all children at presentation. Vitamin K 1, Vitamin K2, tumor necrosis factor alpha (TNF-α), interleukin 1 beta (IL-1β), and interleukin 6 (IL-6) levels searched by enzyme-linked immuno-sorbent assay.
Results: The study was conducted with 155 children: 84 children with FS and 71 children in febrile control group. Serum vitamin K1 and vitamin K2 were also higher in FS group than the controls. The results of statistical analysis showed that vitamin K1 and K2 levels were correlated with TNF-α, IL-1β and IL-6 levels. The median vitamin K1 and vitamin K2 levels of children experiencing their first FS were higher than children with recurrent FS. The type of FS has no effect on serum vitamin K1 and vitamin K2 levels.
Conclusion: This study demonstrates that the vitamin K levels in children with febrile seizure was higher than control group. These new findings may contribute to clarifying the etiopathogenesis of FS.

Keywords : Children, febrile seizure, Vitamin K
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