ISSN : 2146-3123
E-ISSN : 2146-3131

Adipoparacrinology: an Emerging Field in Biomedical Research
George N. Chaldakov 1, Anton Tonchev 1, Neşe Tunçel 2, Jerzy Beltowski 3, Marco Fiore 4, Gorana Ranćić 5, Plamen Panayotov 6, Nikolai Evtimov 7, Alexander Hinev 8, Deyan Anakievski 8, Peter Ghenev 9, Luigi Aloe 10
1Laboratory of Cell Biology, Medical University, Varna, Bulgaria
2Department of Physiology, Medical Faculty, Osmangazi University, Eskişehir, Turkey
3Department of Pathophysiology, Medical University, Lublin, Poland
4Institute of Cellular Biology and Neurobiology, CNR, Rome, Italy
5Department of Histology and Embryology, Medical Faculty, Niš, Serbia
6Department of Cardiac Surgery, University St Marina Hospital, Varna, Bulgaria
7Clinic of Urology, St Anna Hospital, Varna, Bulgaria
8Clinic of Urology, University St Marina Hospital, Varna, Bulgaria
9Department of General and Clinical Pathology, Medical University, Varna, Bulgaria
10Institute of Cell Biology and Neurobiology, National Research Council (CNR), Rome, Italy
DOI : 10.5152/balkanmedj.2012.022
Pages : 2-9

Abstract

White adipose tissue (WAT) is a dynamic multicellular assembly composed of adipocytes and stromovascular cells, including fibroblasts, endothelial and immune cells, nerve fibers, and stem cells. In humans, WAT is a responsive and secretory (endocrine and paracrine) tissue partitioned into two large depots (subcutaneous and visceral) and many small depots associated with the heart, blood vessels, major lymph nodes, prostate gland, ovaries and mammary glands. This short review conceptualizes evidence for the paracrine activity of adipose tissue in founding a new research field, designated adipoparacrinology. Here we focus on (i) epicardial and periadventitial adipose tissue in atherogenesis, (ii) mammary gland-associated adipose tissue in breast cancer, and (iii) periprostatic adipose tissue in prostate cancer. Other examples include: (i) mesenteric adipose tissue in Crohn's disease, (ii) lymph node-associated (perinodal) adipose tissue in Crohn's disease and HIV-associated adipose redistribution syndrome, (iii) infrapatellar fat pad (Hoffa's fat pad) in knee osteoarthritis, (iv) orbital adipose tissue in thyroid-associated (Graves') ophthalmopathy, and (v) parasellar region-associated adipose tissue in brain disorders. The therapy aspect of adipoparacrinology is also discussed.

Keywords : Adipokines, atherosclerosis, breast cancer, epicardial adipose tissue, NGF, periadventitial adipose tissue, periprostatic adipose tissue, prostate cancer
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