ISSN : 2146-3123
E-ISSN : 2146-3131

Protective Effect of Quercetin Against Renal Toxicity Induced by Cadmium in Rats
Tevfik Aktoz 1, İrfan Hüseyin Atakan 1, Mehmet Kanter 2, Yeşim Hülya Uz 2, Cevat Aktaş 3
1Departments of Urology, Medical Faculty of Trakya University, Edirne
2Department of Histology and Embryology, Faculty of Medicine, Trakya University, Edirne, Turkey
3Department of Histology and Embryology, Faculty of Medicine, Namık Kemal University, Tekirdağ, Turkey
DOI : 10.5152/balkanmedj.2011.014
Pages : 56-61

Abstract

Objective: The aim of the present study was to examine the protective effect of quercetine (QE) against cadmium (Cd)-induced renal toxicity.

Material and Methods: A total of 24 male Wistar albino rats were divided into three groups: control, Cd-treated and Cd-treated with QE; each group containing 8 animals. The Cd-treated group was injected subcutaneously with CdCl2 dissolved in saline in the dose of 2 ml/kg/day for 30 days, resulting in a dosage of 1 mg/kg Cd. The rats in the QE treated groups were given QE (15 mg/kg body weight) once a day intraperitoneally starting 2 days prior to Cd injection during the study period.

Results: The renal histology in Cd-treated rats showed mesangial expansion, thickening of capsular basement membranes, glomerular basement membranes and tubular basement membranes, characterized by an increase in periodic acid Schiff (PAS)-positive areas as compared with control animals. With the QE treatment, despite the presence of only a few swollen glomeruli, we noticed a marked protection of renal structure when compared with the Cd-treated rats. Furthermore, QE pretreatment resulted in increased proliferating cell nuclear antigen (PCNA) immunoreactivity and decreased the activity of Terminal Transferase dUTP Nick End Labeling (TUNEL).

Conclusion: These findings suggest that QE may attenuate Cd-induced renal toxicity.

Keywords : Cadmium, immunohistochemistry, quercetin, renal toxicity, TUNEL
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