ISSN : 2146-3123
E-ISSN : 2146-3131

Comparison of Analgesic Effects of Intraperitoneal Lornoxicam and Ropivacaine Administration in Laparoscopic Cholecystectomy
Ceyhun Mehmedov 1, Öner Menteş 1, Abdurrahman Şimşek 1, Can Keçe 1, Gökhan Yağcı 1, Ali Harlak 1, Ahmet Coşar 2, Tufan Turgut 1
1Departments of General Surgery, Gülhane Military Medical School, Ankara
2Departments of Anesthesiology, Gülhane Military Medical School, Ankara
DOI : 10.5174/tutfd.2008.01046.2
Pages : 142-149

Abstract

Objectives: In this randomized prospective study, we investigated the effects of lornoxicam vs. ropivacaine for the management of postoperative pain in patients undergoing elective laparoscopic cholecystectomy.

Patients and Methods: Patients were randomized into three groups and received 150 mg (80 mL) ropivacaine or 16 mg lornoxicam (80 mL) or placebo (80 mL saline) via multi-regional intraperitoneal instillation and port sites infiltration. Patient-controlled analgesia (PCA) device was used. Tramadol 50 mg tolerable dose, 5 mg/hour basal infusion, bolus dose 20 mg, locked 30 min, 4 hour limit were applied as 200 mg. Postoperative pain was assessed with 100-mm visual analog scale (VAS) at rest, while coughing, and during mobilization. Pain scores were recorded in the post-anesthesia care unit, and at 2, 4, 8, 12,18 and 24 h after the surgery.

Results: At 24 h, VAS scores at rest and while coughing were found significantly lower in ropivacaine and lornoxicam group when compared with control group (p=0.047). The percentage of patients needing tramadol was significantly lower with ropivacaine and lornoxicam compared with control (p<0.001, p=0.018). There was no statistically significant difference between ropivacaine and lornoxicam group.

Conclusion: Multi-regional, intraperitoneal instillation and port site infiltration of ropivacaine and lornoxicam during laparoscopic cholecystectomy reduces the postoperative pain.

Keywords : Laparoscopic cholecystectomy; ropivacaine; lornoxicam; postoperative pain
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