ISSN : 2146-3123
E-ISSN : 2146-3131

Previous Antibiotic Exposure and Antimicrobial Resistance Patterns of Acinetobacter Spp and Pseudomonas aeruginosa Isolated From Patients with Nosocomial Infections
Zorana M. Djordjevic 1, Marko M. Folic 2, Slobodan M. Jankovic 3
1Department of Control Hospital Infections, Kragujevac Centre Clinical, Kragujevac, Serbia
2Department of Pharmacology, Kragujevac Centre Clinical, Kragujevac, Serbia
3Department of Pharmacology, Kragujevac University School of Medicine, Kragujevac, Serbia
DOI : 10.4274/balkanmedj.2016.1844

Background: An alarming spread of antibiotic-resistant bacteria causing healthcare-associated infections is extensively reported in recent medical literature.
Aims: To compare trends of antimicrobial consumption and development of resistance among isolates of Acinetobacter spp and Pseudomonas aeruginosa causing hospital infections.
Study Design: Cross-sectional study.
Methods: A study was conducted in tertiary health care institution in central Serbia, during the 7-years period, between January 2009 and December 2015. Incidence rate of infections caused by Acinetobacter or Pseudomonas, as well as their resistance density to commonly used antibiotics were calculated. Utilization of antibiotics was expressed by number of defined daily doses spent per 1000 patient-days.
Results: Statistically significant increase trend of resistance density was noted for Acinetobacter, but not for Pseudomonas, to third-generation cephalosporins (p=0.008), aminoglycosides (p=0.005), carbapenems (p=0.003), piperacillin/tazobactam (p=0.025), ampicillin/sulbactam (p=0.009) and tigecycline (p=0.048). Strong correlation was found between resistance density in Acinetobacter spp and use of carbapenems (r=0.786; p=0.036), tigecycline (r=0.955; p=0.001) and aminoglycosides (r =-0.856; p=0.014).
Conclusion: Our study showed that there is an association between resistance density of Acinetobacter spp and utilization of of carbapenems, tigecycline and aminoglycosides. A multifaceted intervention is needed to decrease incidence rate of Acinetobacter and Pseudomonas hospital infections, as well as their resistance density to available antibiotics.

Keywords : Nosocomial infections, Pseudomonas aeruginosa, Acinetobacter, antimicrobial resistance
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