ISSN : 2146-3123
E-ISSN : 2146-3131

Evaluation of Pancreatic Malign Tumours with Mangafodipir Trisodium
Yasin Argımak 1, Alptekin Tosun 1, Bilge Çakır 1, Osman Temizöz 2
1Trakya Üniversitesi Tıp Fakültesi Radyoloji Anabilim Dalı, Edirne
2Departments of Radiology Medical Faculty of Trakya University, Edirne
Pages : 53-58

Abstract

Objectives: Our study aimed to assess the diagnostic capabilities of mangafodipir trisodium (Mn-DPDP)- enhanced magnetic resonance imaging for the evaluation of pancreatic malign mass.

Patients and Methods: Magnetic resonance images of 17 patients (7 females, 10 males; mean age 63.2±12 years; range 36 to 80 years) suspected of pancreatic tumor by abdominal ultrasonography and computed tomography findings, were examined in terms of signal to noise (S/N) and contrast to noise (C/N) ratios before and after administration of Mn-DPDP using T1 A SE, Fat Sat T1 A SE and GRE T1 A sequences.

Results: Before and after administration of Mn-DPDP, the increase in S/N ratios of normal pancreatic parenchyma were found as 22.81%, 32.88% and 20% in T1 A SE, Fat Sat T1 A SE and GRE T1 A sequences, respectively. The increase in C/N ratios obtained from signal intensity values of normal pancreatic tissue and tumor were found as 58.69%, 125.41% and 62.06% in T1 A SE, Fat Sat T1 A SE and GRE T1 A sequences, respectively. Furthermore, in all sequences, before and after contrast medium administration, the increase of C/N ratios were found statistically significant (paired Student's t test, p<0.0001).

Conclusion: The differences of C/N ratio using Mn-DPDP as a contrast agent may contribute to the diagnosis of pancreatic malign masses.

Keywords : Mangafodipir trisodium (Mn-DPDP); contrast-tonoise ratio; magnetic resonance imaging; pancreas; tumor

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