ISSN : 2146-3123
E-ISSN : 2146-3131

Serum Angiogenic and Anti-angiogenic Markers in Pregnant Women with Placenta Percreta
Hacer Uyanıkoğlu1, Adnan İncebıyık1, Ahmet B. Turp1, Güler Çakmak1, Sibel Sak1, Neşe G. Hilali1
1Department of Obstetrics and Gynecology, Harran University School of Medicine, Şanlıurfa, Turkey
DOI : 10.4274/balkanmedj.2016.1890


Backgrounds: Placenta percreta (PP) is the morbidly adherent form of placental invasion abnormalities. The pathology that underlies the PP is poorly understood.
Aims: To compare the levels of circulating vascular endothelial growth factor (VEGF), placental growth factor (PlGF), and soluble fms like tyrosine kinase 1 (sFlt-1) in pregnant women with PP and control group.
Study Design: Case-control study.
Methods: Twenty two women who underwent cesarean section (CS) due to PP and 22 women who underwent CS for other obstetric reasons were included in this study. The diagnosis of the PP was defined as extreme trophoblastic invasion involving serosa of the uterus. Venous blood samples collected for biochemical comparison of circulating VEGF, PlGF, and sFlt-1 from all pregnant women.
Results: Women with PP were significantly older, had higher gravidity, and more frequently received antenatal steroids, blood transfusions, and delivered at an earlier gestational age when compared to control. In women with PP, preoperative circulating levels of VEGF, PlGF, and sFlt-1 were lower than the controls (p<0.001, p<0.001 and p<0.05, respectively). While the postoperative levels of VEGF and sFlt-1 levels were higher in PP (p=0.001, p<0.001, respectively), PlGF levels were similar in both groups.
Conclusion: The findings of this study suggest that a decrease in VEGF, PlGF, and sFlt-1 levels may be related with PP etiopathogenesis.
Keywords : Invasion, placenta percreta, PlGF, sFlt-1, VEGF