ISSN : 2146-3123
E-ISSN : 2146-3131

Intravenous Dexketoprofen versus Intravenous Paracetamol for Dysmenorrhea: A Randomized Controlled Trial
Mustafa Serinken1, Cenker Eken2, Özgür Karcıoğlu3
1Department of Emergency Medicine, Pamukkale University School of Medicine, Denizli, Turkey
2Department of Emergency Medicine, Akdeniz University School of Medicine, Antalya, Turkey
3Clinic of Emergency Medicine, İstanbul Training and Research Hospital, İstanbul, Turkey
DOI : 10.4274/balkanmedj.2016.0536

Background: Dysmenorrhea is one of the most common acute pain disorders among women of reproductive age.
Aims: The present study aimed to compare the effects of IV paracetamol to dexketoprofen in patients presented with primary dysmenorrhea to the emergency department.
Study Design: Randomized Controlled Trial.
Methods: Patients over 18 years old presented with pelvic pain related to menstruation were accepted as eligible for the study. Study patients received 1 gr paracetamol or 50 mg dexketoprofen in 100 ml normal saline with a 4-5 minutes infusion via intravenous route. Pain intensity was measured by visual analogue scale at 15 and 30 minutes. Patients were randomized and assigned to either of the two study arms via sealed envelopes. The study drugs were identical in color and thus the personnel and the patients were blinded to the study drug. Dexketoprofen group comprised 49 patients and paracetamol group 50 patients in the final analysis.
Results: The mean age of the study subjects was 20.9±2.5 and the mean duration of the pain was 1.9±1.7 (median: 1, IQR: 1 to 2) hours. Both dexketoprofen (median change: 33, 95% CI 24 to 38) and paracetamol (median change: 21, 95% CI: 12 to 32) effectively reduced the pain at 15 minutes, which was repeated at 30th minutes (median change: 63, 95% CI: 57 to 65 vs 55.5, 95% CI: 50 to 59; respectively). Pain improvement in dexketoprofen group was better than paracetamol group at 15 (median difference: 8; 95% CI: 0 to 16, p:0.048) and 30 (median difference: 6; 95% CI: 1 to 12, p:0.028) minutes, which reached to statistically significance but not clinically significance.
Conclusion: Intravenous dexketoprofen has better VAS scores at 15 and 30 minutes compared to intravenous paracetamol but with clinical insignificance.

Keywords : dysmenorrhea, dexketoprofen, paracetamol, emergency department, pain treatment

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