ISSN : 2146-3123
E-ISSN : 2146-3131

Comparison of Interpolation Methods in the Diagnosis of Carpal Tunnel Syndrome
Veysel Alcan1, Murat Zinnuroğlu2, Gülçin Kaymak Karataş2, Elliot Bodofsky3
1Dikmen Vocational and Technical Anatolian High School, Ankara, Turkey
2Department of Physical Medicine and Rehabilitation, Gazi University School of Medicine, Ankara, Turkey
3Department of Physical Medicine and Rehabilitation, Cooper Medical School of Rowan University, Camden, New Jersey, USA
DOI : 10.4274/balkanmedj.2017.1314

Background: Diagnosis of carpal tunnel syndrome is based on clinical symptoms, examination findings, and electrodiagnostic studies. For carpal tunnel syndrome, the most useful part is nerve conduction studies. However, nerve conduction study can result in ambiguous or false negative results, particularly for mild carpal tunnel syndrome. Increasing the number of nerve conduction study tests improves accuracy, but also increases time, cost, and discomfort. To improve accuracy without additional testing, the Terminal Latency index and Residual Latency are additional calculations using the minimum number of tests. Recently, the median sensory-ulnar motor latency difference was devised as another way to improve diagnostic accuracy for mild carpal tunnel syndrome.
Aims: Median sensory-ulnar motor latency difference, Terminal Latency index and Residual Latency were compared for diagnostic accuracy by severity.
Study Design: Diagnostic accuracy study.
Methods: A total of 657 subjects were retrospectively enrolled. The carpal tunnel syndrome group consisted of 546 subjects with carpal tunnel syndrome by nerve conduction study (all severities). The control group consisted of 121 subjects with no hand symptoms and normal nerve conduction study. All statistical analyses were performed using SAS. Means were compared using the one-way ANOVA test with the Bonferroni adjustment. Sensitivity, specificity, positive predictive value and negative predictive value were compared including Receiver Operating Characteristic curve analysis.
Results: For mild carpal tunnel syndrome, median sensory-ulnar motor latency difference showed the higher specificity and positive predictive value rates (0.967 and 0.957, respectively) than Terminal Latency index (0.603 and 0.769, respectively) and Residual Latency (0.818 and 0.858, respectively). The area under the Receiver Operating Characteristic was highest for the median sensory-ulnar motor latency difference (0.889), followed by the Residual Latency (0.829), and the Terminal Latency index last (0.762). Differences were statistically significant (median sensory-ulnar motor latency difference is the most accurate). For moderate carpal tunnel syndrome, sensitivity and specificity rates of Residual Latency (0.989 and 1.000) and Terminal Latency index (0.983 and 0.975) were higher than median sensory-ulnar motor latency difference (0.866 and 0.958). Differences in area under the Receiver Operating Characteristic curve were not significantly significant, but median sensory-ulnar motor latency difference sensitivity was lower. For severe carpal tunnel syndrome, Residual Latency yielded 1.000 sensitivity, specificity, positive predictive value, negative predictive value and area beneath Receiver Operating Characteristic Curve. Differences in area under the Receiver Operating Characteristic curve were not significantly significant.
Conclusion: Median sensory-ulnar motor latency difference is the best calculated parameter for diagnosing mild carpal tunnel syndrome. It requires just a simple calculation and no additional testing. Residual Latency and Terminal Latency index are also useful in diagnosing mild to moderate carpal tunnel syndrome.

Keywords : Carpal tunnel syndrome, diagnosis, interpolation, nerve conduction

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