ISSN : 2146-3123
E-ISSN : 2146-3131

Recent Progress in Pathology and Genetics of Pilocytic and Pilomyxoid Astrocytomas
Cristine Ding1,2, Tarik Tihan1
1Division of Neuropathology, Department of Pathology, UCSF School of Medicine, California, USA
2Department of Pathology, Tan Tock Seng Hospital, Singapore
DOI : 10.4274/balkanmedj.2018.1001

Pilocytic and Pilomyxoid Astrocytomas constitute one of the most common gliomas in children and young adults, and are considered indolent neoplasms with long overall survival probability. The genetic characteristics of these neoplasms have been well characterized, and the deeper understanding of molecular alterations has led to novel treatment strategies and approaches. Currently, we can account for some of the unusual behavior of these neoplasms such as oncogene-induced senescence and associated spontaneous regression, anaplastic transformation and cerebrospinal dissemination. However, there are still enigmatic issues with these tumors that are often considered "chronic diseases". We review the classical and less common clinical pathological and genetic features of these indolent gliomas.

Keywords : Astrocytoma, glioma, mitogen-activated protein kinase pathway, oncogene-induced senescence, pilocytic, pilomyxoid

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