ISSN : 2146-3123
E-ISSN : 2146-3131

Clinicopathologic Features of Gastroenteropancreatic Neuroendocrine Tumors (GEP-NET) s: A Single-Center Experience
Tuğba Akın Telli1, Ece Esin1, Şuayib Yalçın1
1Department of Medical Oncology, Hacettepe University Cancer Institute, Ankara, Turkey
DOI : 10.4274/balkanmedj.galenos.2020.2020.1.126

Background: Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are a heterogenous group of neoplasms originating from the neuroendocrine system of the gastrointestinal tract and pancreas. There aren’t many large well-designed studies investigating NETs in Turkey.
Aims: To define the clinicopathologic, demographic and survival features of patients with GEPNETs.
Study Design: Retrospective observational cohort study.
Methods: In this study, we reviewed hospital records of patients. The data was analyzed retrospectively and we investigated clinical, pathological and survival features and prognosis of patients with GEP-NETs (n=128) admitted to medical oncology department between 2003 and 2014. Survival curve estimation was performed using the Kaplan-Meier method. Univariate and multivariate Cox regression models were utilized to assess prognostic factors for survival.
Result: Among 128 patients with GEP-NETs, 61 (47.7%) were female and 67 (52.3%) were male. The most common site of tumor was stomach (36.7%). The most common stage at diagnosis was stage 4 (40.9%). The median follow-up period was 37 months. Three-years overall survival (OS) rate was 78% and 5-years OS rate was 69%. The factors that can significantly affect OS rate were clinical stage, grade, presence of metastasis at diagnosis and Ki-67 proliferation index; these factors were associated with 3 and 5-years OS rate. Moreover, grade (Hazard ratio (HR)=8.34, 95% CI: 2.16-32.22, p=0.01) and presence of metastasis at diagnosis (HR=3.18, 95% CI: 1.30-7.77, p=0.01) predicted OS independently in multivariate model, when adjusted for age and gender.
Conclusion: Higher grade and presence of metastasis at diagnosis were found to be negative independent prognostic indicators of survival in patients with GEP-NETs.

Keywords : Gastroenteropancreatic neuroendocrine tumor, carcinoid tumour, neuroendocrine tumor

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