ISSN : 2146-3123
E-ISSN : 2146-3131

Balanced Chromosomal Translocation of Chromosomes 6 and 7: A Rare Male Factor of Spontaneous Abortions
Sefa Resim 1, Erkan Efe 1, Ateş Kadıoğlu 2, Tolga Akman 3, Ayşe Gül Bayrak 3
1Department of Urology, Kahramanmaraş Sütçü İmam University Faculty of Medicine, Kahramanmaraş, Turkey
2Department of Urology, İstanbul University Faculty of Medicine, İstanbul, Turkey
3Department of Internal Diseases, İstanbul University Faculty of Medicine, İstanbul, Turkey
DOI : 10.5152/balkanmedj.2012.107
Pages : 250-252

Abstract

Background: Carriers of structural chromosomal rearrangements such as Robertsonian or reciprocal translocations have an increased risk of spontaneous abortion and producing offspring with genetic abnormalities. 

Case Report: We report a man with balanced chromosomal translocations located at 6p22, and 7q22. His wife has a history of four spontaneous abortions. 

Conclusion: Couples with a history of abortions should be investigated cytogenetically, after other causes of miscarriages are excluded. The possibility of spontaneous abortions can be reduced with preimplantation genetic diagnosis (PGD) before embryo transfer.

Keywords : Balanced chromosomal translocation, spontaneous abortions, preimplantation genetic diagnosis

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