ISSN : 2146-3123
E-ISSN : 2146-3131

Gaye Güler Tezel 1, Ebru Şener 2, Çisel Aydın 3, Sevgen Önder 1
1Department of Pathology, Hacettepe University School of Medicine, Ankara, Turkey
2Clinic of Pathology, Erzurum Regional Training and Research Hospital, Erzurum, Turkey
3Clinic of Pathology, Haydarpaşa Numune Training and Research Hospital, İstanbul, Turkey
DOI : 10.4274/balkanmedj.2017.0297


Aims:Epidermal growth factor receptor mutation analysis in non-small cell lung cancer is important for selecting patients who will receive treatment with tyrosine kinase inhibitors. In this study, we aimed to investigate the prevalence of epidermal growth factor receptor mutations and mutation patterns in the Turkish population.
Study Design:Retrospective cross-sectional study.
Methods:We retrospectively reviewed molecular pathology reports of 959 cases with lung cancer analyzed for EGFR mutation. We analyzed all 4 epidermal growth factor receptor exon mutations using a real-time polymerase chain reaction platform.
Results:In this study, the epidermal growth factor receptor mutation rate in the Turkish population was 16.7% (160 of 959). Epidermal growth factor receptor mutation frequency was significantly higher in women (37.1%, n=96) compared to men (9.1%, n=64) (p<0.001). In addition, the epidermal growth factor receptor mutation rate was higher in the adenocarcinoma histologic type (p<0.001). Patients with mutations were older than patients without mutations were (p=0.003). The most frequent mutations were exon 19 deletions (48.8%, 78/160) and exon 21 L858R point mutations (38.1.1%, 61/160). We also detected compound mutation patterns in 3 cases (1.9%).
Conclusion:In our study, the prevalence of epidermal growth factor receptor mutations in the Turkish population was slightly higher compared to the Caucasian population and lower compared to the East Asian population. We found mutation rates higher in women, a histological type of adenocarcinoma, and in the elderly population.

Keywords:Non-small cell lung cancer, epidermal growth factor receptor mutation, ethnicity, Turkish population.

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