Hydatid disease is a parasitic infection caused by echinococcus granulosus and echinococcus alveolaris. This infection is characterized by cyst formation and the liver is the most commonly involved organ. Hydatid cysts can rupture during surgical operation and allergic reaction may occur. In this case report, we presented a patient who developed an allergic reaction characterized by urticaria during the operation of a hidatic cyst in the liver.