ISSN : 2146-3123
E-ISSN : 2146-3131

Evaluation of MIF -173 G/C Polymorphism in Turkish Patients with Ankylosing Spondylitis
Çevik Gürel 1, Ahmet İnanır 2, Ayşe Feyda Nursal 3, Akın Tekcan 4, Aydın Rüstemoğlu 1, Serbülent Yiğit 1
1Department of Medical Biology, Gaziosmanpaşa University School of Medicine, Tokat, Turkey
2Department of Physical Medicine and Rehabilitation, Gaziosmanpaşa University School of Medicine, Tokat, Turkey
3Department of Medical Genetics, Giresun University, School of Medicine, Giresun, Turkey
4Ahi Evran University School of Health, Kırşehir, Turkey
DOI : 10.5152/balkanmedj.2016.141103
Pages : 614-619


Background: Ankylosing spondylitis (AS) is a chronic inflammatory disease mainly affecting the spine and sacroiliac joints. Macrophage migration inhibitory (MIF) factor is a regulatory cytokine that inhibits random immune cell migration. MIF gene promoter polymorphisms play a role in the progression of several inflammatory disorders.

Aims: To investigate the relationship between the MIF gene -173 G/C single-nucleotide polymorphism (SNP) and AS.

Study Design: Cross-sectional study.

Methods: In this study, a total of 161 AS and 194 normal controls were recruited. The MIF gene -173 G/C SNP was analyzed by polymerase chain reaction using the restriction fragment length polymorphism method. 

Results: There was no significant difference between groups in terms of genotype distribution (p>0.05). When wild-type G/G and G/C+C/C genotypes are compared in terms of clinical characteristics, there is a significant difference between the average age and the duration of disease in AS patients (p<0.05). 

Conclusion: No significant relationship between AS disease and MIF -173 G/C polymorphism was found. MIF -173 G/C polymorphism (C allele) may affect the time of onset and the duration of disease in AS patients.

Keywords : Ankylosing spondylitis, macrophage migration inhibitory factor, polymorphism
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