Abstract

Objectives: This study was designed to compare serum total and lipid-bound sialic acid levels obtained from patients with and without coronary obstruction.

Patients and Methods: Serum total and lipid-bound sialic acid levels were determined in 42 patients (29 men, 13 women; mean age 58 years; range 32 to 75 years) with angiographically documented coronary obstruction and in 35 patients (22 men, 13 women; mean age 54 years; range 39 to 75 years) with no obstruction. Serum total and lipid-bound sialic acid levels were determined by the methods of Warren and Katopodis, respectively. The results were compared with the use of one-way ANOVA test.

Results: Serum total and lipid-bound sialic acid levels were significantly higher in patients with coronary obstruction (81.01±10.10 mg/dl and 33.59±7.00 mg/dl, respectively) when compared with those of patients with no obstruction (65.18±10.23 mg/dl and 25.28±7.40 mg/dl, respectively) (p<0.001).

Conclusion: The measurement of serum total and lipid-bound sialic acid levels may be useful in distinguishing between patients with and without coronary obstruction.

Keywords : Acute-phase proteins; angina pectoris/blood; biological markers/blood; cerebrovascular disorders/blood; chest pain/blood; coronary angiography; coronary arteriosclerosis; coronary