ISSN : 2146-3123
E-ISSN : 2146-3131

Pneumococcal Nasopharyngeal Carriage in Young Healthy Children After Pneumococcal Conjugate Vaccine in Turkey
Ahmet Arvas 1, Haluk Çokuğraş 1, Emel Gür 1, Nevriye Gönüllü 2, Zeynep Taner 2, Hrisi Bahar Tokman 2
1Department of Paediatrics, İstanbul University Cerrahpaşa School of Medicine, İstanbul, Turkey
2Department of Medical Microbiology, İstanbul University Cerrahpaşa School of Medicine, İstanbul, Turkey
DOI : 10.4274/balkanmedj.2016.1256
Pages : 362-366

Aims: To determine the prevalence of nasopharyngeal carriage of Streptococcus pneumoniae in healthy children aged 0-6 years who were vaccinated with pneumococcal conjugate vaccine.
Methods: This cross-sectional study was conducted on 150 healthy Turkish children between 1 month and 6 years of age. Serotyping was performed and risk factors of carriage were evaluated.
Results: The overall carriage rate was 14%. Vaccine type serotypes were determined in 17 (12.6%) children who received full-dose PCV13 vaccine. The highest carriage rate was observed among children younger than 24 months (76.2%). In multivariate analysis, respiratory infection in recent months, age, attendance at a day-care center and antibiotic usage were not statistically significant risk factors for carriage. Overall, S. pneumoniae strains were considered as penicillin susceptible and antimicrobial resistance was limited.
Conclusion: We observed a low rate of pneumococcal carriage in children after PCV13 implementation compared with that of children receiving PCV7. Although it was reduced, vaccine serotype colonization in PCV13-vaccinated children remains persistent.

Keywords : Children, nasopharyngeal carriage, pneumococcal conjugate vaccine, Streptococcus pneumoniae
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