ISSN : 2146-3123
E-ISSN : 2146-3131

The evaluation of vitamin K status in children with febrile seizure
Kürşat Bora Carman1, Yasemin Karal2, Gül Gülen Mert3, Arzu Ekici4, Peren Perk5, Coşkun Yarar1, Çağatay Nuhoğlu6, Gürkan Bozan7, Ömer Kılıç7, Meltem Dinleyici7, Sabiha Şahin7, Emrah Atay8, Uğur Tokdemir7, Baver Demir5, Ener Çağrı Dinleyici7, Dinleyici EC EFES Study Group
1Department of Pediatric Neurology, Eskisehir Osmangazi University School of Medicine, Eskişehir, Turkey
2Department of Pediatrics, Trakya University School of Medicine, Edirne, Turkey
3Department of Pediatric Neurology, Çukurova University School of Medicine, Adana, Turkey
4Clinic of Pediatric Neurology, Yüksek İhtisas Hospital, Bursa, Turkey
5Gaziantep Children’s Hospital, Gaziantep, Turkey
6Department of Pediatrics, Haydarpaşa Numune Eduction and Training Hospital, İstanbul, Turkey
7Department of Pediatrics, Eskişehir Osmangazi University School of Medicine, Eskişehir, Turkey
8Department of Public Health, Eskişehir Osmangazi University School of Medicine, Eskişehir, Turkey
DOI : 10.4274/balkanmedj.galenos.2020.2020.5.70
Pages : 116-120

Background: Febrile seizure is the most common neurological disorder in childhood. The exact pathophysiology of febrile seizures is unknown. Recent studies showed the role of vitamin K in nonhematological and inflammatory disorders. This study aimed to investigate the serum vitamin K levels in children with febrile seizures.
Aims: To evaluate vitamin K levels in children with febrile seizures.
Study Design: Prospective case-control study.
Methods: This multicenter study examined representative populations in 8 different cities in Turkey between April 1, 2018 and April 1, 2019. Blood samples were taken from all children at presentation. Vitamin K1, vitamin K2, tumor necrosis factor-alpha, interleukin 1 beta, and interleukin 6 levels were determined by enzyme-linked immunosorbent assay.
Results: A total of 155 children were included in the study—84 children with febrile seizures and 71 children in febrile control group. Serum vitamin K1 and vitamin K2 levels were also higher in children with febrile seizures than in the controls. The results of statistical analysis showed that vitamin K1 and vitamin K2 levels were correlated with tumor necrosis factor-alpha, interleukin 1 beta, and interleukin 6 levels. The median vitamin K1 and vitamin K2 levels of children experiencing their first febrile seizure were higher than those in children with recurrent febrile seizures. Type of febrile seizure has no effect on serum vitamin K1 and vitamin K2 levels.
Conclusion: In children with febrile seizures, vitamin K levels are higher than those in the control group. These new findings may contribute to elucidating the etiopathogenesis of febrile seizures.

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