Abstract

Background: The effects of dietary copper and magnesium intake, the geriatric nutritional risk index (GNRI), and the systemic inflammation response index (SIRI) on stroke risk in the elderly remain unclear.

Aims: To examine the relationships between dietary copper and magnesium intake, GNRI, SIRI, and stroke risk in the elderly.

Study Design: Cross-sectional study.

Methods: Data from 7,157 elderly participants in National Health and Nutrition Examination Survey 2007-2016 were analyzed using multifactorial logistic regression, subgroup analysis, smooth curve fitting, threshold effect analysis, mediation analysis, and sensitivity analysis.

Results: Higher dietary copper and magnesium intake were significantly and linearly associated with lower stroke risk. SIRI was positively associated with stroke risk, while GNRI had a stable protective effect. In fully adjusted models, medium- and high-level copper and magnesium intake were positively associated with GNRI and negatively associated with SIRI. GNRI mediated 4.4% and 5.5% of the associations between copper and magnesium intake and stroke risk, respectively; SIRI mediated 3.4% and 2.9%, respectively.

Conclusion: Higher dietary copper and magnesium intake are associated with reduced stroke risk in the elderly, with GNRI and SIRI exerting modest mediating effects.