Evaluation of Frequencies of HLA-A, B and DR in Thracian Population and Examination of its Relationship With Balkan Populations

Trakya'da Yaşayan Popülasyonun HLA-A, B ve DR Sıklığı Yönünden Değerlendirilmesi ve Balkan Popülasyonları ile Akrabalığının Gösterilmesi

Funda Sibel Pala ¹, Kıymet Tabakçıoğlu ¹, Çetin Algüneş ¹, imran Kurt Ömürlü ²

¹Trakya Üniversitesi Tıp Fakültesi Tıbbi Biyoloji Anabilim Dalı, Edirne
²Trakya Üniversitesi Tıp Fakültesi Biyoistatistik Anabilim Dalı, Edirne

Pages : 189-195

Abstract

Objectives: In this study, human leukocyte antigen (HLA) allel frequencies of Thracian Turkish population were determined.

Study Design: The study group consisted of 105 tissue donors who live in Thrace region of Turkey for three generations and have similar linguistic features. Polymerase chain reaction-sequencespecific primer (PCR-SSP) method was used for genotyping of HLA-A, B and DRB1 alleles. The most frequent HLA alleles were HLA-A*02 (20.5%), HLA-B*35 (22.9%) and HLA-DR*11 (17.6%).

Results: Conclusion: In this study also, HLA-DR allel frequencies were compared in order to determine the relationship between other Turkish populations and Balkan populations. It is observed that Thracian Turkish population has similar HLA-DR distributions with Balkan populations.