Autosomal Dominant Polycystic Disease is Associated with Depressed Levels of Soluble Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand

Funda Sarı ¹, Arzu Didem Yalçın ², Gizem Esra Genç ³, Metin Sarıkaya ¹, Atıl Bisgin ⁴, Ramazan Çetinkaya ¹, Saadet Gümüşlü ³

¹Division of Nephrology, Department of Internal Medicine, Antalya Training and Research Hospital, Antalya, Turkey
²Department of Internal Medicine, Antalya Training and Research Hospital, Antalya, Turkey
³Department of Biochemistry, Akdeniz University School of Medicine, Antalya, Turkey
⁴Department of Clinical and Experimental Medicine, University of Linköping School of Health Sciences, Linköping, Sweden

DOI : 10.5152/balkanmedj.2016.150685

Pages : 512-516

Abstract

Background: Autosomal dominant polycystic kidney disease (ADPKD) is characterized by multiple, large renal cysts and impaired kidney function. Although the reason for the development of kidney cysts is unknown, ADPKD is associated with cell cycle arrest and abundant apoptosis of renal tubular epithelial cells.

Aims: We asked whether serum-soluble TNF-related apoptosis-inducing ligand (sTRAIL) might underlie ADPKD.

Study Design: Case-control study.

Methods: Serum sTRAIL levels were measured in 44 patients with ADPKD and 18 healthy volunteers. The human soluble TRAIL/Apo2L ELISA kit was used for the in vitro quantitative determination of sTRAIL in serum samples.

Results: Mean serum sTRAIL levels were lower in patients with ADPKD as compared to the control group (446.9±103.1 and 875.9±349.6 pg/mL, p<0.001). Serum sTRAIL levels did not differ among stages of renal failure in patients with ADPKD. There was no correlation between serum sTRAIL levels and estimated glomerular filtration rate in patients with ADPKD (p>0.05).

Conclusion: Our results show that ADPKD patients have depressed sTRAIL levels, indicating apoptosis unrelated to the stage of chronic renal failure.