ISSN : 2146-3123
E-ISSN : 2146-3131

The Antioxidant Effects of Taurine, Melatonin and N-Acetylcysteine in Cadmium-Induced Lung Injury
Nurettin Aydoğdu 1, Hakan Erbaş 2, Kadir Kaymak 3
1Departments of Physiology, Medical Faculty of Trakya University, Edirne
2Trakya Üniversitesi Tıp Fakültesi, Biyokimya Anabilim Dalı, Edirne
3Trakya Üniversitesi Tıp Fakültesi Fizyoloji Anabilim Dalı, Edirne
Pages : 43-48

Abstract

Objectives: The potential protective and therapeutic effects of taurine, melatonin and N-acetylcysteine (NAC), which are recognized as antioxidant agents, in cadmium chloride (CdCl2)-induced lung injury were compared.

Study Design: Ninety male Sprague-Dawley rats were divided into 9 groups. During the 3 months treatment period, group 1 received drinking water, group 2 200 ppm CdCl2, group 3 200 ppm CdCl2 and 1% taurine, to, group 4, 200 ppm CdCl2 and 0.02% melatonin, and group 5 received 200 ppm CdCl2 and 0.5% NAC all added into drinking water in each group. After, groups 6, 7, 8 and 9 received 200 ppm CdCl2 in their drinking water for 3 months, group 6 was given drinking water, group 7, 4% taurine, group 8, 0.08% melatonin and group 9, 2% NAC, each for 7 days.

Results: Melatonin and NAC which were given for protective purposes, increased the decreased glutathione levels. The 3 substances that were administered for both protective and therapeutic purposes, decreased the increased malondialdehyde levels, one of the end products of lipid peroxidation.

Conclusion: Taurine, melatonin and NAC play protective and therapeutic roles in CdCl2 induced lung injury.

Keywords : Acetylcysteine; cadmium; glutathione; melatonin; taurine

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