ISSN : 2146-3123
E-ISSN : 2146-3131

Erythrocyte Arginase Activity in Lung Cancer Patients
Selma Süer Gökmen 1, Reyhan Yıldız 1, Şendoğan Gülen 1, Erhan Tabakoğlu 2, Gündeniz Altıay 3, Ebru Yavuz 4
1Trakya Üniversitesi Tıp Fakültesi, Biyokimya Anabilim Dalı, Edirne
2Trakya Üniversitesi Tıp Fakültesi, Göğüs Hastalıkları Anabilim Dalı, Edirne, Turkey
3Trakya Üniversitesi Tıp Fakültesi Göğüs Hastalıkları Anabilim Dalı, Edirne
4Trakya Üniversitesi Tıp Fakültesi, Biyoistatistik Anabilim Dalı, Edirne
Pages : 76-81

Abstract

Objectives: We investigated blood erythrocyte arginase activity in lung cancer patients and the effect of cell type and extrapulmonary metastasis on this activity.

Patients and Methods: The study included 46 lung cancer patients (mean age 63.1 years) and 29 healthy subjects (mean age 57.2 years). Erythrocyte arginase activity was determined with the use of the Geyer-Dabich method. Erythrocyte arginase activity was compared between patients with small cell lung cancer (n=15), non-small cell lung cancer (n=31), extrapulmonary metastases (n=23), and no metastasis (n=23).

Results: Compared to healthy controls, erythrocyte arginase activity was significantly increased in all lung cancer patients (p<0.01), and in patient groups with small cell lung cancer (p<0.05), non-small cell lung cancer (p<0.01), extrapulmonary metastases (p<0.01), and no metastasis (p<0.01). On the other hand, erythrocyte arginase activity did not differ significantly between patients with small cell lung cancer and non-small cell lung cancer, and between patients with and without extrapulmonary metastases.

Conclusion: Our data suggest that, compared to healthy subjects, erythrocyte arginase activity is significantly increased in lung cancer patients, with no additional effect of cell type or extrapulmonary metastases.

Keywords : Arginase/blood; carcinoma, non-small-cell lung; carcinoma, small cell; erythrocytes/blood; lung neoplasms/blood; neoplasm metastasis

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