ISSN : 2146-3123
E-ISSN : 2146-3131

Analyses of C-Reactive Protein, Endothelial Nitric Oxide Synthase and Interleukin-6 Gene Polymorphisms in Adolescents with a Family History of Premature Coronary Artery Disease: A Pilot Study
Ataç Çelik 1, Fatih Altunkaş 1, Kayıhan Karaman 1, Metin Karayakalı 1, Köksal Ceyhan 1, Mustafa Özçetin 2, Ömer Ateş 3, İlker Akar 4, İlker İnce 4, Murat Yalçın 5, Fatih Koç 6
1Department of Cardiology, Gaziosmanpaşa University Faculty of Medicine, Tokat, Turkey
2Department of Pediactics, Süleymaniye Obstetrics and Gynecology Training and Research Hospital, İstanbul, Turkey
3Department of Medical Biology, Gaziosmanpaşa University Faculty of Medicine, Tokat, Turkey
4Department of Cardiovascular Surgery, Gaziosmanpaşa University Faculty of Medicine, Tokat, Turkey
5Department of Cardiology, GATA Haydarpaşa Military Hospital, İstanbul, Turkey
6Department of Cardiology, Akdeniz University Faculty of Medicine, Antalya, Turkey
DOI : 10.5152/balkanmedj.2015.151190
Pages : 397-402


Background: Family history of premature atherosclerosis imposes a high risk to people. The relationship between atherosclerosis and gene polymorphisms of various biomarkers such as Endothelial Nitric Oxide Synthase (eNOS), C-Reactive Protein (CRP), and Interleukin-6 (IL-6) has shown in previous studies.

Aims: The major aim of the study was to evaluate the CRP, eNOS, and IL-6 gene polymorphisms in a group of adolescents who have a parental history of early coronary artery disease (CAD).

Study Design: Case-control study.

Methods: Thirty-six volunteers with a father with obstructive CAD during the first four decades and 46 subjects with a father with normal coronary arteries documented with coronary angiography were included in the study. Polymerase chain reaction-restriction fragment length polymorphism techniques were used to analyze CRP, eNOS, and IL-6 polymorphisms.

Results: We did not find any differences between the two groups with regard to age, sex, body mass index, renal functions, systolic and diastolic blood pressures, lipid profile, and fasting glucose, hemoglobin, and high sensitivity CRP. A significant difference was only observed in IL-6-572 G/C genotype distribution and allele frequency between two groups (Pc=0.036 OR=3.48 CI (95%) 1.17-10.32).

Conclusion: The present study showed a significant association between the IL-6-572 G/C gene polymorphism (presence of C allele) and adolescents with a parental history of premature CAD.

Keywords : Atherosclerosis, C-reactive protein, polymorphism, nitric oxide synthase, interleukins

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