ISSN : 2146-3123
E-ISSN : 2146-3131

The Impact of FDG-PET for the Preoperative Management of Patients with Colorectal Cancer
Zafer Kılbaş 1, Taner Yiğit 1, Köksal Öner 1, Orhan Kozak 1, Seyfettin Ilgan 2, Seyfettin Ilgan 2, Nuri Arslan 2, Öner Menteş 3, Turgut Tufan 4
1Gülhane Askeri Tıp Akademisi, Genel Cerrahi Anabilim Dalı, Ankara, Türkiye
2Gülhane Askeri Tıp Akademisi, Nükleer Tıp Anabilim Dalı, Ankara, Türkiye
3Departments of General Surgery, Gülhane Military Medical School, Ankara
4Departments of Anesthesiology, Gülhane Military Medical School, Ankara
DOI : 10.5174/tutfd.2009.02767.2
Pages : 133-137

Abstract

Objective: Whole-body fluorodeoxyglucose-positron emission tomography (FDG-PET) has proved effective in the diagnosis of recurrent colorectal cancer (CRC) and in the monitoring of cancer therapy. However there have been limited studies considering the effect of FDG-PET in the initial evaluation of CRC. We analysed how FDG-PET affects the management of patients with CRC preoperatively.

Material and Methods: A prospective study of 26 consecutive patients with known or suspected CRC was undertaken. The patients were evaluated by computed tomography (CT) and FDG-PET. FDG-PET results were compared with those of CT and correlated with histopathologic findings or with clinical course.

Results: FDG-PET had a sensitivity of 96% and positive predictive value of 100% for the diagnosis of primary cancer, while CT had values of 68% and 95%, respectively. FDG-PET was superior to CT in detecting additional metastatic disease with a sensitivity of 89%, while CT had 33%. FDG-PET resulted in altered management for 8 patients of whom three avoided inappropriate surgery.

Conclusion: It is concluded that FDG-PET is highly sensitive for the diagnosis and staging of patients with CRC. Its use in conjunction with CT results in a more accurate selection of patients for surgical treatment with curative intent.

Keywords : Colorectal cancer, FDG-PET, patient management

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