ISSN : 2146-3123
E-ISSN : 2146-3131

Efficacy and Tolerability of Sertaconazole Nitrate in Mycotic Vaginitis
Cüneyt Eftal Taner 1, Bülent Elveren 1, Deniz Balsak 1, Mustafa Oğuz Aygören 1, Süleyha Hilmioğlu Polat 2
1İzmir Ege Doğumevi ve Kadın Hastalıkları Eğitim ve Araştırma Hastanesi Kadın Doğum Kliniği, İzmir
2Ege Üniversitesi Tıp Fakültesi Mikrobiyoloji Anabilim Dalı, İzmir
Pages : 204-208


Objectives: In this research, single-dose of 300 mg sertaconazole nitrate ovule in mycotic vaginitis has been evaluated in terms of clinical and microbiological efficacy and safety.

Patients and Methods: The study included 177 patients (mean age 31.8±7.8 years; range 15 to 53 years) who applied to our polyclinics with vaginitis complaints. Patients having cottage cheese-like discharge, vaginal pH<4.5, Whiff test (-) were accepted as mycotic vaginitis. To determine mycotic agents in vaginal discharge, samples were cultured in Sabouraud glucose agar. As a treatment, patients were administered a single-dose of 300 mg sertaconazole nitrate ovule. Its clinical and microbiological aspects have been evaluated in the first visit, a week after and finally one month after the first visit. Symptoms related to vaginitis, clinical and microbiological recovery rates and adverse effects have been noted.

Results: All symptom scores were significantly lower in the second visit, and all except dysuria complaint in the third visit. Clinical recovery rates in the second and third visit were in 76.0% and 79.5%. According to mycotic culture test results, the microbiologic recovery rates were 88.8% in the second and 91.4% in the third visits.

Conclusion: Single-dose sertaconazole nitrate ovule was evaluated as a convenient, symptom-relieving and safe treatment for mycotic vaginitis.

Keywords : Mycotic vaginitis; sertaconazole; efficacy and tolerability.
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