ISSN : 2146-3123
E-ISSN : 2146-3131

Adherence to Nucleoside/Nucleotide Analogue Treatment in Patients with Chronic Hepatitis B
Emin Ediz Tütüncü1, Rahmet Güner2, Yunus Gürbüz1, Ayşe Kaya Kalem3, Barış Öztürk1, İmran Hasanoğlu3, İrfan Şencan1, Mehmet A. Taşyaran2
1Department of Infectious Diseases and Clinical Microbiology, University of Health Sciences, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey
2Department of Infectious Diseases and Clinical Microbiology, Ankara Yıldırım Beyazıt University School of Medicine, Ankara, Turkey
3Clinic of Infectious Diseases and Clinical Microbiology, Ankara Atatürk Training and Research Hospital, Ankara, Turkey
DOI : 10.4274/balkanmedj.2016.1461

Background: Adherence to medication is an important aspect of preventing drug resistance and treatment failure in patients receiving nucleos(t)ide analogues for chronic hepatitis B.
Aims: To assess adherence to nucleoside/nucleotide analogues in chronic hepatitis B treatment and to determine factors associated with non-adherence.
Study Design: Cross-sectional study.
Methods: The study enrolled 85 chronic hepatitis B patients who had been receiving nucleoside/nucleotide analogues for ≥3 months. A questionnaire was completed by patients themselves, and adherence was evaluated based on patients’ self-reporting. The use of at least 95% of the drugs in the previous month was considered as adequate adherence.
Results: Adherence was adequate in 82.4% of patients. Female gender (p=0.003), unemployment (p=0.041) and lower monthly family income (p=0.001) were related to lower adherence. Better adherence was significantly linked to adequate basic knowledge regarding chronic hepatitis B (p=0.049), longer treatment duration than 12 months (p<0.001), previous use of other medications for chronic hepatitis B (p=0.014) and regular follow-up by the same physician (p<0.001).
Conclusion: Counselling patients about their disease state and the consequences of non-adherence is an important intervention for enhancing adherence. Naïve patients should be followed up more frequently to reinforce adherence.

Keywords : Medication adherence, chronic hepatitis B, treatment outcome, nucleoside/nucleotide analogues
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