ISSN : 2146-3123
E-ISSN : 2146-3131

Correlation of serum CCL3/MIP-1α levels with disease severity in postmenopausal osteoporotic females
Hui Wan1, Tie-Yong Qian1, Xiao-Jing Hu1, Ci-You Huang1, Wei-Feng Yao1
1Department of Endocrinology, Nanjing Medical University Affiliated Wuxi Second Hospital, Wuxi, China
DOI : 10.4274/balkanmedj.2017.1165

Background: The pro-inflammatory protein chemokine cytokine ligand 3 is well-established as a vital regulator of bone resorption and osteoclasts stimulation.
Aims: We sought to investigate if serum chemokine cytokine ligand 3 levels correlated with disease severity in postmenopausal osteoporosis females.
Study Design: Cross-sectional Study
Methods: 82 postmenopausal osteoporotic females, 76 postmenopausal non-osteoporotic women and 80 healthy female at childbearing age were recruited. The total hip, femoral neck, and L1–L4 spine bone mineral density was assessed by the dual energy x-ray absorptiometry. Serum chemokine cytokine ligand 3 concentrations were examined by commercial ELISA kit. The serum inflammatory cytokine IL-6 and tumor necrosis factor-alpha and bone metabolic markers carboxy-terminal crosslinked and tartrate-resistant acid phosphatase 5b were also examined. The visual analogue scores and Oswestry Disability Index were utilized to assess clinical severity.
Results: Patients in the postmenopausal osteoporotic females group had significantly increased serum chemokine cytokine ligand 3 levels than those in the postmenopausal non-osteoporotic group (40.9±15.1 pg/mL vs 24.2±8.7 pg/mL, P<0.001) and control group (40.9±15.1 pg/mL vs 23.9±9.1 pg/mL, P<0.001). Serum chemokine cytokine ligand 3 levels were negatively related to bone mineral density at the total hip (r=-0.345, P = 0.002), femoral neck (r=-0.329, P = 0.003) and L1–L4 lumbar spine (r=-0.354, P = 0.001) and correlated positively with visual analogue scores (r=0.413, P <0.001) and Oswestry Disability Index (r=0.360, P<0.001). Moreover,,serum chemokine cytokine ligand 3 levels were associated with increased tumor necrosis factor-alpha (r=0.305, P=0.005), IL-6 (r=0.288, P=0.008), terminal crosslinked and tartrate-resistant acid phosphatase 5b (r=0.371, P<0.001) and carboxy-terminal crosslinked (r=0.317, P=0.004) levels. All associations were still significant following adjusting for BMI and age.
Conclusion: Chemokine cytokine ligand 3 may be a useful biomarker that can be used to predict disease severity of postmenopausal osteoporosis. Therapies targeting chemokine cytokine ligand 3 and its related signaling ways to inhibit and delay osteoclastogenesis process deserves further investigation.

Keywords : Chemokine cytokine ligand 3, postmenopausal osteoporosis, disease severity
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