ISSN : 2146-3123
E-ISSN : 2146-3131

Early Retinal and Choroidal Coat Thickness Changes After Intravitreal Dexamethasone Implant Injection for Diabetic Macular Edema
Fatih Horozoğlu1, Sever Özkan1
1Department of Ophthalmology, Namık Kemal University School of Medicine, Tekirdağ, Turkey
DOI : 10.4274/balkanmedj.2017.1013

Background: Intravitreal steroid injection is one of the treatment choices in diabetic macular edema (DME). Dexamethasone (Dx) implant is the most novel form of intravitreal steroid therapy. Macular thickness improvement is well known effect of Dx implant however; subfoveal choroidal coat thickness (SFCT) changes need to be investigated.
Aims: To evaluate the early central macular thickness (CMT) and SFCT alterations after single dose dexamethasone implant injection in DME.
Study Design: Retrospective cross-sectional study.
Methods: We identified 29 patients with DME (29 eyes) who underwent optical coherence tomography (OCT) and fundus fluoroscein angiography (FFA). All patients received a single dose intravitreal Dx implant and were followed for CMT and SFCT alterations for the post-injection first hour, first day, first week, first month and third month.
Results: The preoperative mean CMT and SFCT measurements were 592.3±122.3 (412-879) μm and 264.8±53.7 (165-397) μm, respectively. CMT measurements significantly decreased from the first hour (p<0.050) and kept decreasing till 3 month (p<0.001); while SFCT decrement was just significant at the first day (p<0.05). When we compared the decrease in SFCT and CMT, 1 hour was similar, however not significant, 1.5% SFCT and 5% CMT decrease was, respectively (p>0.050). CMT decrease rate was significantly higher than SFCT at 1 day, 1 week, 1 month and 3 month (p<0.001).
Conclusion: Intravitreal Dx implant has got a meaningful effect on CMT in patients with DME while SFCT decreases significantly at first hour and first day.

Keywords : Dexamethasone implant, diabetic macular edema, choroidal thickness, choroidal coat
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