ISSN : 2146-3123
E-ISSN : 2146-3131

The Adipokine Profile and the Cardio-Metabolic Risk in Non-Obese Young Adults
Marina Ruxandra Otelea1, Adrian Streinu-Cercel1,2, Cristian Băicus1,3, Maria Nitescu1,2
1Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
2Institute for Infectious Diseases ‘Matei Bals’, Bucharest, Romania
3Clinical Hospital Colentina, Bucharest, Romania
DOI : 10.4274/balkanmedj.2018.0789

Background: Young, non obese adults are considered at low risk for cardio-metabolic diseases, although markers of unhealthy metabolic state are not uncommon findings in this population. The dysfunction of the adipose tissue, evaluated by the adipokine profile, significantly influences lipid and glucose metabolism and the low grade systemic inflammation.
Aims: To determine the relation between the adipose tissue dysfunction and already confirmed indicators of the cardio-metabolic risk: the atherogenic index of plasma (AIP), the lipid accumulation product (LAP), the homeostatic model assessment of insulin resistance (HOMA-IR) and the low grade inflammation markers: interleukin 6 and high sensitivity C-reactive protein (hsCRP).
Study Design: cross-sectional.
Methods: We recruited 93 non obese, healthy young adults. Anthropometric, lipid profile, inflammatory markers and adipokines were measured. An abnormal adipokine profile (high leptin to adiponectin ratio) was considered as marker of a dysfunctional adipose tissue. The correlation between the leptin to adiponectin ratio, on one side, and the anthropometric measurements, the AIP, the LAP, HOMA-IR, the interleukin 6 and the hsPrC, on the other side, was determined.
Results: We found a direct correlation between the abnormal adipokine profile and the cardio-metabolic risk indicators mentioned above, except for the low grade inflammatory markers. In the regression model derived from our data, leptin to adiponectin ratio was best correlated with the unfavorable plasma lipid profile, as estimated by the AIP (r=0.097, CI=0.015-0.180, p=0.021). Significanly higher leptin to adiponectin ratio was found in the insulin resistant group (p=0.012) and in the highest LAP quartile (p=0.032).
Conclusion: Our results suggest that high leptin to adiponectin ratio is a suitable candidate for the cardio-vascular and metabolic risk assessment in young, non-obese population.

Keywords : Leptin, adiponectin, atherosclerosis, insulin resistance
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