ISSN : 2146-3123
E-ISSN : 2146-3131

Prognostic Affect of Predominant Histologic Subtypes in Resected Pulmonary Adenocarcinomas
Demet Yaldız1, Şeyda Örs Kaya2, Kenan Can Ceylan2, Arkın Acar2, Zekiye Aydoğdu3, Soner Gürsoy2, Sadık Yaldız1
1Department of Thoracic Surgery, Celal Bayar University School of Medicine, Manisa, Turkey
2Clinic of Thoracic Surgery, University of Health Sciences, İzmir Dr. Suat Seren Chest Diseases and Thoracic Surgery Training and Research Hospital, İzmir, Turkey
3Clinic of Pathology, University of Health Sciences, İzmir Dr. Suat Seren Chest Diseases and Thoracic Surgery Training and Research Hospital, İzmir, Turkey
DOI : 10.4274/balkanmedj.galenos.2019.2019.1.130

Background: Histologic predominant subtypes were reported as a predictor of survival in pulmonary adenocarcinoma.
Aims: To evaluate the predictive value of histologic classification in resected lung adenocarcinoma using the International Association for the Study of Lung Cancer (IASLC)/American Thoracic Society (ATS)/European Respiratory Society (ERS), and WHO (2015) classification system.
Study Design: Cross-sectional study.
Methods: Histologic classification of a large cohort of 491 patients with resected (stages I to III) lung adenocarcinoma was retrospectively analyzed. The tumors were classified according to their predominant component (lepidic, acinar, papillary, solid, micropapillary, and mucinous), and their predictive value were assessed for clinicopathologic characteristics, and overall survival.
Results: The patient cohort were comprised of 158 (32.2%) solid-predominant, 150 (30.5%) acinar-predominant, 80 (16.3%) papillary-predominant, 75 (15.3%) lepidic-predominant, 22 (4.5%) mucinous, 5 (1.0%) micropapillary, and 1(0.2%) adenocarcinoma in situ. Overall 5-year survival of 491 patients were found to be 51.8%. Lepidic, acinar, mucinous adenocarcinoma had 70.9%, 59.0%, and 66.6%  5-year survival, respectively and there was no statistically significant difference between them.Whereas solid,  papillary and micropapillary predominant histologic pattern had 41.0%, 40.5% and 0.0% 5-year survival, respectively. Compared to other histologic subtypes; solid predominant adenocarcinoma and papillary predominant adenocarcinoma harbored significantly lower survival to lepidic (p<0.001, p=0.002), acinar (p<0.001, p=0.008), and mucinous (p=0.048, p=0.048) subtypes respectively. The survival difference between solid and papillary subtype was not found statistically significant (p=0.67).
Conclusion: Solid and papillary predominant adenocarcinoma was found to be poor prognostic factors in resected invasive lung adenocarcinoma.

Keywords : Pulmonary adenocarcinoma, papillary subtype, solid Subtype
Viewed : 111
Downloaded : 138