ISSN : 2146-3123
E-ISSN : 2146-3131

Effect of Varicocele and Its Treatment on Testosterone in Hypogonadal Men with Varicocele: Review of The Literature
Selahittin Çayan1, Erdem Akbay1, Barış Saylam1, Ateş Kadıoğlu2
DOI : 10.4274/balkanmedj.galenos.2020.2020.1.85

Varicocele might cause deterioration in Leydig cell functions, and is a significant risk factor for hypogonadism. Some controversial issues have been to treat hypogonadal men with varicocele. Symptomatic hypogonadal men with varicocele might have two options to be treated either with testosterone replacement therapy or treatment of varicocele. However, both approaches have some advantages and disadvantages. This review summarizes effect of varicocele on plasma total testosterone level, and addresses whether varicocele repair is effective to improve testosterone levels in hypogonadal men with varicocele.

Experience from large clinical studies in the literature suggests that varicocele repair may increase serum testosterone level in men with varicocele and testosterone deficiency. Varicocele repair could be offered to men with clinically palpable varicocele and hypogonadism. As the treatment method, microsurgical varicocele repair could be preferred to provide the best improvement. Another advantage of varicocele repair for hypogonadism, instead of exogenous testosterone treatment, would be saving fertility status in men who will desire a child in the future. However, further studies are required to clarify varicocele related Leydig cell dysfunction, and also to advice hypogonadal patients for sufficient effectiveness of the varicocele repair.

Keywords : Adult, Urinary tract, Testicular, Testosterone, Varicocele
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