ISSN : 2146-3123
E-ISSN : 2146-3131

Blood Pressure Management Following Large Vessel Occlusion Strokes: A Narrative Review
Saurav Das1, Kevin Denny John2, Satheesh Kumar Bokka1, Kerri Remmel3,4, Ozan Akça3,4
1Department of Neurology, Louisville University School of Medicine, Louisville, Kentucky, USA
2University of Louisville, School of Medicine, Louisville, Kentucky, USA
3Department of Anesthesiology and Perioperative Medicine, Stroke ICU, Louisville University Hospital, Louisville, Kentucky, USA
4Comprehensive Stroke Clinical Research Program, University of Louisville, Louisville, Kentucky, USA
DOI : 10.4274/balkanmedj.galenos.2020.2020.4.196
Pages : 253-259


Stroke is one of the leading causes of morbidity and mortality worldwide. Intravenous tissue plasminogen activator and mechanical thrombectomy comprise the two major treatments for acute ischemic stroke. Tissue plasminogen activator has been used for more than two decades and guidelines for hemodynamic management following tissue plasminogen activator administration are well established. However, mechanical thrombectomy is a relatively newer therapy and there is a paucity of evidence regarding hemodynamic management following large vessel occlusion strokes. The important tenets guiding the pathophysiology of large vessel occlusion strokes include understanding of cerebral autoregulation, collateral circulation, and blood pressure variability. In this narrative review, we discuss the current American Heart Association-American Stroke Association guidelines for the early management of acute ischemic stroke during different phases of the illness, encountered at different sections of a hospital including the emergency room, the neuro-interventional suite, and the intensive care unit. There is emerging evidence with regard to post-recanalization blood pressure management following large vessel occlusion strokes. Future research directions will include real-time blood pressure variability assessments, identifying the extent of impaired autoregulation, and providing guidelines related to range and personalized blood pressure trajectories for patients following large vessel occlusion strokes.

Keywords : Blood pressure variability, cerebral autoregulation, endovascular thrombectomy, hypertension, ischemic stroke, large vessel occlusion, mechanical thrombectomy, perfusion, recanalization
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