ISSN : 2146-3123
E-ISSN : 2146-3131

Interferon Gamma in Sickness Predisposing to Mycobacterial Infectious Diseases
Betül Gemici Karaaslan1, Jérémie Rosain2,3,4,5, Jacinta Bustamante2,3,4,5, Ayça Kıykım1
1Department of Pediatric Allergy and Immunology, İstanbul University-Cerrahpaşa, Cerrahpaşa Faculty of Medicine, İstanbul, Türkiye
2Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Necker Hospital for Sick Children, Paris, France
3University of Paris Cité, Imagine Institute, Paris, France
4Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, Assistance Publique Hôpitaux de Paris (AP-HP), Paris, France
5St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, USA
DOI : 10.4274/balkanmedj.galenos.2024.2024-8-18
Pages : 326-332

Abstract

In recent decades, the prevalence of inborn errors of immunity has increased, necessitating the development of more effective treatment and care options for these highly morbid conditions. Due to these “experiments of nature,” the complicated nature of the immune system is being revealed. Based on the functional and molecular tests, targeted therapies are now being developed which offer a more effective approach and reduce damage. This study aimed to investigate a key cytokine of the cellular immune response, interferon‐gamma (IFN-γ), which is linked to Mendelian susceptibility to Mycobacterial disease, and its potential as a therapeutic option for IFN-γ deficiency.

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