ISSN : 2146-3123
E-ISSN : 2146-3131

KRAS Mutation in Small Cell Lung Carcinoma and Extrapulmonary Small Cell Cancer
Hilmi Kodaz 1, Ebru Taştekin 2, Bülent Erdoğan 1, İlhan Hacıbekiroğlu 1, Hilmi Tozkır 3, Hakan Gürkan 3, Esma Türkmen 1, Bora Demirkan 3, Sernaz Uzunoğlu 1, İrfan Çiçin 1
1Department of Medical Oncology, Trakya University School of Medicine, Edirne, Turkey
2Department of Medical Pathology, Trakya University School of Medicine, Edirne, Turkey
3Department of Medical Genetics, Trakya University School of Medicine, Edirne, Turkey
DOI : 10.5152/balkanmedj.2016.150610
Pages : 407-410


Background: The orbital complications account for about 80% of all complications secondary to acute rhinosinusitis. If the treatment is not correct and in time, orbital complications could progress rapidly, leading to optic neuritis, cavernous sinus thrombophlebitis or life-threatening intracranial complications.

Aims: To evaluate the therapeutic efficacy of conservative therapy for the patients with orbital cellulitis and endoscopic sinus surgery (ESS) performed on patients with subperiosteal abscess (SPA) secondary to acute rhinosinusitis in children.

Study Design: Retrospective cross-sectional study.

Methods: The retrospective study included 31 pediatric patients with orbital complications secondary to acute rhinosinusitis. In all cases, intensive treatment was initiated with a combination of oral or intravenous antibiotics, glucocorticoid and gelomyrtol forte after admission. ESS was performed if an improvement in the condition of patients did not occur after 48 hours. However, the patients with orbital SPA, motility disorders of eyeball or decreased vision received ESS immediately within 24 hours.

Results: Sixteen patients were cured by conservative therapy and 15 patients by ESS. All of the signs and symptoms disappeared after conservative therapy or ESS. There were no recurrences within the follow-up period of 1 to 8 years.

Conclusion: Conservative therapy is an effective method for patients with inflammatory edema and most cases of orbital cellulitis in children. SPA can be cured by ESS.

Keywords : Small cell lung cancer, extrapulmonary small cell carcinoma, KRAS mutation
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