ISSN : 2146-3123
E-ISSN : 2146-3131

Sıçanlarda İyonizan Radyasyonla Oluşturulan Katarakt Üzerine Curcuminin Koruyucu Etkisi
Seher Çimen Özgen1, Dikmen Dökmeci1, Çetin Hakan Karadağ1, Özgür Gündüz1, Meryem Akpolat2, Hakan Erbaş3, Ömer Benian4, Cem Uzal5, Fatma Nesrin Turan6
1Department of Pharmacology, Faculty of Medicine, Trakya University, Edirne, Turkey
2Department of Histology and Embryology, Faculty of Medicine, Trakya University, Edirne, Turkey
3Department of Biochemistry, Faculty of Medicine, Trakya University, Edirne, Turkey
4Department of Ophtalmology, Faculty of Medicine, Trakya University, Edirne, Turkey
5Department of Radiation Oncology, Faculty of Medicine, Trakya University, , Edirne, Turkey
6Department of Biostatistics, Faculty of Medicine, Trakya University, Edirne, Turkey
DOI : 10.5152/balkanmedj.2012.038

Summary

Abstract

Objective: The aim of the study was to determine the protective effect of curcumin against ionizing radiation-induced cataract in the lens of rats.

Material and Methods: Rats were divided into six groups. Group 1: Control, Group 2: Dimethyl sulfoxide (DMSO), Group 3: DMSO+curcumin, Group 4: Irradiation, Group 5: Irradiation+DMSO, Group 6: Irradiation+DMSO+curcumin. A 15 Gy total dose was given to 4, 5, 6 groups for radiation damage. Curcumin (100 mg/kg) was dissolved in DMSO and given by intragastric intubation for 28 days. At the end of the experiment, lenses were graded and enucleated. The lenticular activity of the antioxidant enzymes, total antioxidant and glutathione peroxidase (GSH-Px), and the malondialdehyde (MDA) were measured.

Results: 100% Cataract was seen in the irradiation group. Cataract rate fell to 40% and was limited at grade 1 and 2 in the curcumin group. In the irradiation group, antioxidant enzyme levels were decreased, MDA levels were increased. There was an increase in antioxidant enzyme levels and a significant decrease in MDA in the group which was given curcumin.

Conclusion: Curcumin has antioxidant and radioprotective properties and is likely to be a valuable agent for protection against ionizing radiation. Hence, it may be used as an antioxidant and radioprotector against radiation-induced cataractogenesis.

JEL code: I180 Health

Total Times Cited: 9 (Updated on Dec. 2017- WoS)

Keywords : Katarakt, curcumin, iyonizan radyasyon, lipid peroksidasyonu, oksidatif stres, radioprotektif

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