ISSN : 2146-3123
E-ISSN : 2146-3131

Clinical, Demographic, and Radiological Characteristics of Patients Demonstrating Antibodies Against Myelin Oligodendrocyte Glycoprotein
Sümeyye Koç1, Sedat Şen2, Yüksel Terzi3, Ferah Kızılay4, Serkan Demir5, Dürdane Bekar Aksoy6, Fatma Kurtuluş7, Nuray Bilge8, Egemen Idilman9, Cihat Uzunköprü10, Serdal Güngör11, Vedat Çilingir12, Özlem Ethemoğlu13, Cavit Boz14, Haluk Gümüş15, Ahmet Kasım Kılıç16, Ayşin Kısabay17, Levent Sinan Bir18, Ömer Faruk Turan19, Aysun Soysal20, Mesrure Köseoğlu20, Gülnur Tekgöl Uzuner21, Hasan Bayındır13, Sibel Canbaz Kabay22, Mustafa Çam23, Vildan Yayla24, Hüseyin Tan8, Abdülcemal Özcan11, Özlem Taşkapıoğlu25, Muammer Korkmaz26, Yusuf Tamam27, Yılmaz İnanç28, Hüsnü Efendi29, Dilcan Kotan30, Mehmet Fatih Yetkin31, Adnan Burak Bilgiç32, Hikmet Saçmacı33, Serpil Demirci34, Yahya Çelik35, Turan Poyraz36, Murat Terzi2
1Department of Neuroscience, Ondokuz Mayıs University Institute of Graduate Studies, Samsun, Türkiye
2Department of Neurology, Ondokuz Mayıs University Faculty of Medicine, Samsun, Türkiye
3Department of Statistics, Ondokuz Mayıs University Faculty of Science and Literature, Samsun, Türkiye
4Department of Neurology, Akdeniz University Faculty of Medicine, Antalya, Türkiye
5Clinic of Neurology, Sancaktepe Şehit Prof. Dr. İlhan Varank Training and Research Hospital, İstanbul, Türkiye
6Department of Neurology, Tokat Gaziosmanpaşa University Faculty of Medicine, Tokat, Türkiye
7Clinic of Neurology, Antalya Training and Research Hospital, Antalya, Türkiye
8Department of Neurology, Atatürk University Faculty of Medicine, Erzurum, Türkiye
9Department of Neurology, Dokuz Eylül University Faculty of Medicine, İzmir, Türkiye
10Department of Neurology, İzmir Katip Çelebi University Faculty of Medicine, İzmir, Türkiye
11Department of Pediatric Neurology, İnönü University Faculty of Medicine, Malatya, Türkiye
12Department of Neurology, Van Yüzüncü Yıl University Faculty of Medicine, Van, Türkiye
13Department of Neurology, Harran University Faculty of Medicine, Şanlıurfa, Türkiye
14Department of Neurology, Karadeniz Teknik University Faculty of Medicine, Trabzon, Türkiye
15Clinic of Neurology, Selçuk University Faculty of Medicine, Konya, Türkiye
16Department of Neurology, University of Health Sciences Türkiye, Kartal Dr. Lütfi Kırdar Training and Research Hospital, İstanbul, Türkiye
17Department of Neurology, Manisa Celal Bayar University Faculty of Medicine, Manisa, Türkiye
18Department of Neurology, Pamukkale University Faculty of Medicine, Denizli, Türkiye
19Department of Neurology, Bursa Uludağ University Faculty of Medicine, Bursa, Türkiye
20Clinic of Neurology, University of Health Sciences Türkiye, Bakırköy Prof. Dr. Mashar Osman Training and Research Hospital, İstanbul, Türkiye
21Department of Neurology, Eskişehir Osmangazi University Faculty of Medicine, Eskişehir, Türkiye
22Clinic of Neurology, Kütahya Evliya Çelebi Training and Research Hospital, Kütahya, Türkiye
23Department of Neurology, Çanakkale Onsekiz Mart University Faculty of Medicine, Çanakkale, Türkiye
24Clinic of Neurology, Bakırköy Dr. Sadi Konuk Training and Research Hospital, İstanbul, Türkiye
25Department of Neurology, Acıbadem University Faculty of Medicine, İstanbul, Türkiye
26Department of Neurology, Muğla Sıtkı Koçman University Faculty of Medicine, Muğla, Türkiye
27Department of Neurology, Dicle University Faculty of Medicine, Diyarbakır, Türkiye
28Department of Neurology, Kahramanmaraş Sütçü İmam University Faculty of Medicine, Kahramanmaraş, Türkiye
29Department of Neurology, Kocaeli University Faculty of Medicine, Kocaeli, Türkiye
30Clinic of Neurology, Sakarya Training and Research Hospital, Sakarya, Türkiye
31Department of Neurology, Erciyes University Faculty of Medicine, Kayseri, Türkiye
32Clinic of Neurology, Samsun Training and Research Hospital, Samsun, Türkiye
33Department of Neurology, Bozok University Faculty of Medicine, Yozgat, Türkiye
34Department of Neurology, Süleyman Demirel University Faculty of Medicine, Isparta, Türkiye
35Clinic of Neurology, Private Ada Tıp Hospital, Sakarya, Türkiye
36Clinic of Neurology, Private Medifema Hospital, İzmir, Türkiye
DOI : 10.4274/balkanmedj.galenos.2024.2024-1-97
Pages : 272-279

Abstract

Background: Optic neuritis, myelitis, and neuromyelitis optica spectrum disorder (NMOSD) have been associated with antibodies against myelin oligodendrocyte glycoprotein-immunoglobulin G (anti-MOG-IgG). Furthermore, patients with radiological and demographic features atypical for multiple sclerosis (MS) with optic neuritis and myelitis also demonstrate antibodies against aquaporin-4 and anti-MOG-IgG. However, data on the diagnosis, treatment, follow-up, and prognosis in patients with anti-MOG-IgG are limited.
Aims: To evaluate the clinical, radiological, and demographic characteristics of patients with anti-MOG-IgG.
Study Design: Multicenter, retrospective, observational study.
Methods: Patients with blood samples demonstrating anti-MOG-IgG that had been evaluated at the Neuroimmunology laboratory at Ondokuz Mayıs University’s Faculty of Medicine were included in the study.
Results: Of the 104 patients with anti-MOG-IgG, 56.7% were women and 43.3% were men. Approximately 2.4% of the patients were diagnosed with MS, 15.8% with acute disseminated encephalomyelitis (ADEM), 39.4% with NMOSD, 31.3% with isolated optic neuritis, and 11.1% with isolated myelitis. Approximately 53.1% of patients with spinal involvement at clinical onset demonstrated a clinical course of NMOSD. Thereafter, 8.8% of these patients demonstrated a clinical course similar to MS and ADEM, and 28.1% demonstrated a clinical course of isolated myelitis. The response to acute attack treatment was lower and the disability was higher in patients aged > 40 years than patients aged < 40 years at clinical onset. Oligoclonal band was detected in 15.5% of the patients.
Conclusion: For patients with NMOSD and without anti-NMO antibodies, the diagnosis is supported by the presence of anti-MOG-IgG. Furthermore, advanced age at clinical onset, Expanded Disability Status Scale (EDSS) score at clinical onset, spinal cord involvement, and number of attacks may be negative prognostic factors in patients with anti-MOG-IgG.

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