ISSN : 2146-3123
E-ISSN : 2146-3131

Scleredema Diabeticorum Partially Treated with Low-Dose Methotrexate: a Report of Five Cases
Asena Çiğdem Doğramacı 1, Asena Çiğdem Doğramacı 1, Esin Atik 2, Cumali Gökçe 3
1Department of Dermatology, Medical Faculty of Mustafa Kemal University, Hatay
2Department of Pathology, Faculty of Medicine, Mustafa Kemal University, Hatay, Turkey
3Department of Internal Medicine, Faculty of Medicine, Mustafa Kemal University, Hatay, Turkey
DOI : 10.5152/balkanmedj.2011.027
Pages : 218-221


Scleredema is a rare connective tissue disorder that belongs to a group of scleroderma-like disorders. Although no known curative therapy exists, various specific treatments have been proposed in the literature. In this report, we describe five cases of scleredema partially treated with low-dose methotrexate therapy. All patients have diabetes mellitus type II. All patients were started on methotrexate 15 mg subcutaneously once weekly for 3 months. Biopsy specimens were taken from all patients and were examinated histologically before the treatment and after 3 months of treatment. All cases partially responded to low-dose methotrexate therapy. We believe that methotrexate therapy may be an alternative therapeutic options in scleredema in view of its efficacy.

Keywords : Scleredema, low-dose methotrexate, diabetes mellitus
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